New AI tool maps single cells onto tissue space with unprecedented precision
A new deep learning framework called SCmapST uses a seeded matches strategy to map single-cell gene expression data onto spatial ...
Tag: Spatial transcriptomics
Melanoma’s Genetic Blueprint Builds Immune-Proof Tumor Neighborhoods, Study Finds
Researchers at NYU Grossman School of Medicine show that loss of the NF1 tumor suppressor reorganizes melanoma tumors into immunosuppressive ...
Cancer Cells Defy Quiescence Doctrine as MYC Drives a Proliferative Chemoresistance Program
A sweeping integrated genomics study reveals that chemotherapy-resistant tumors across multiple cancer types share a hyperproliferative, MYC-driven state, identifying the ...
Fibroblasts Recruit Antitumor B Cells in Liver Cancer, Study Finds
Spatial transcriptomic mapping of liver tumors has revealed that CCL19-producing fibroblasts recruit CXCR3-positive B cells to form an antitumor axis ...
Label-Free Raman Imaging Joins Transcriptomics to Map Senescence in Aging Tissue
Researchers have introduced RamanOmics, a label-free strategy combining Raman imaging with spatial and single-cell transcriptomics to map a lipid-linked vibrational ...
RamanOmics Reveals the Hidden Chemical Fingerprint of Aging Cells
A new RamanOmics platform combines Raman chemical imaging with spatial transcriptomics to reveal the biochemical remodeling that defines senescent cells.
Tiny Cell Structures Called Migrasomes May Predict Gastric Cancer Outcomes
A new study links fibroblast-derived migrasome programs and the protein TSPAN4 to gastric cancer progression and builds a highly accurate ...
Spatial Cell Atlas Reveals How a Deadly Tapeworm Rewires the Liver’s Immune Defenses
By combining single-cell RNA sequencing with Visium HD spatial transcriptomics, researchers have built the first spatially resolved atlas of immune ...
New Computational Tool Flags the Tipping Points Where Genes Turn Disease Dangerous
Researchers have developed CRISGI, a computational framework that detects critical transient gene interactions presaging abrupt disease shifts across bulk, single-cell, ...
Single-Cell Map Tracks Rogue T Cell Clones Through Space and Time in Graft-Versus-Host Disease
A spatiotemporal single-cell study of 31 transplant recipients reveals how expanding alloreactive T cell clones acquire tissue-resident memory programs that ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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