RNA Chemical Tag ac4C Reveals Fibroblast Signal That Drives Colorectal Cancer Aggression
A comprehensive profiling study links the ac4C RNA modification to aggressive colorectal cancer and identifies CERCAM in cancer-associated fibroblasts as ...
Tag: Single-Cell RNA Sequencing
Immune Checkpoints on Gamma Delta T Cells Follow Their Own Rules, Study Finds
New research shows that immune checkpoint receptors on human gamma delta T cells are regulated in a lineage- and context-dependent ...
Hidden Scars in the Bone Marrow: Clonal Hematopoiesis Rewrites the Niche Before Cancer Strikes
Single-cell and spatial analyses of human bone marrow reveal that clonal hematopoiesis of indeterminate potential is marked by fibroblast expansion, ...
Scientists Discover a Molecular Switch That Helps Breast Cancer Hide From Immunotherapy
New research shows that the stromal protein RAMP3 drives macrophage-mediated immune exclusion in breast cancer and undermines PD-1 blockade, suggesting ...
Machine Learning Hunt Pinpoints Gene Linked to a Heart Drug’s Lung Damage
An integrated multiomics and machine learning study has identified SERPING1 as a leading candidate biomarker for amiodarone-induced pulmonary fibrosis, with ...
Hidden Genetic Switch Links Cleft Lip Risk Gene to Neural Crest Cells
New research shows that the cleft lip and palate risk gene IRF6 is directly controlled by the transcription factor SOX9 ...
Scientists Map a Hidden Malignant Program in Triple-Negative Breast Cancer
An integrated single-cell and spatial transcriptomic study has identified a triple-negative breast cancer-enriched malignant epithelial program, EP5, linked to aggressive ...
Growing Eye Cells in 3D Reverses Aging and Restores Their Healing Power
A three-dimensional Matrigel culture system reverses replicative aging in human limbal niche cells by upregulating the transcription factor FOSL1, which ...
Light-Patterned DNA Tags Give Single-Cell Sequencing a Sense of Place
A new light-based barcoding technique called scSTAMP-seq stamps spatial coordinates onto individual cells using photocleavable DNA tags, enabling joint transcriptomic ...
Antibiotic Stress Puts Probiotic Bacteria Into Hibernation, Boosting Their Survival
Researchers found that sublethal rifampicin exposure drives Lactobacillus delbrueckii subsp. bulgaricus into a reversible dormant state in which protein aggregates ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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