Rare Sugar D-Allose Rewires a Mitochondrial Stress Circuit to Slow Disc Degeneration
A new study shows that the rare sugar D-allose restores mitophagy, suppresses cGAS–STING signalling and preserves the cytoprotective peptide ADM2 ...
Tag: senescence
Radiation Turns Childhood Brain Tumor Cells Senescent—and Senolytic Drugs Can Kill Them
New research shows that gamma irradiation drives p53 wild-type medulloblastoma cells into a senescent state that senolytic drugs such as ...
How Broken Mitochondria Drive the Scarring That Slowly Kills the Kidneys
A sweeping new review argues that damaged mitochondria in kidney tubule cells act as both trigger and amplifier of the ...
Ancient Viral Fossils Awaken in DNMT3A-Mutant Blood Clones, Fueling Inflammation
New research shows that expanded DNMT3A-mutant blood clones awaken dormant retrotransposable elements and drive interferon and NF-kappaB inflammation, while TET2-mutant ...
Aging Rewires Neutrophils Across the Body, Single-Cell Map Reveals
A single-cell atlas of eight mouse organs shows that aging expands immature, inflammatory neutrophil states that may help drive senescence ...
Hormone asprosin rejuvenates aging stem cells and repairs infarcted hearts in mice
New research shows the hormone asprosin reverses senescence in mesenchymal stem cells through a glycolysis-driven histone lactylation mechanism, and asprosin-engineered ...
Transplanted Mitochondria Rejuvenate the Aging Heart by Restarting Cellular Cleanup
Injecting healthy mitochondria from stem cells into aged mice restored cardiac function by reactivating a blocked mitochondrial waste-disposal pathway controlled ...
Ancient Herb Compound Purges Zombie Cells That Make Arteries Fragile
Researchers report that salvianolic acid A, a compound from Salvia miltiorrhiza, directly binds HSP90α to dismantle the AKT-PERK survival complex ...
When Mitochondrial Calcium Goes Wrong, Plants Sound a Whole-Cell Alarm
New research in Arabidopsis shows that disrupting the mitochondrial calcium uniporter triggers a coordinated unfolded protein response spanning the nucleus, ...
Immune ‘Don’t Eat Me’ Protein CD47 Drives Chemotherapy-Induced Heart Aging in Male Mice
New research shows that the immune checkpoint protein CD47 rises in doxorubicin-damaged hearts and that blocking it with an antibody ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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