Scientists Map the Cellular Drivers of Skin Aging and the Race to Reverse Them
A comprehensive new review details how senescent fibroblasts, macrophages, keratinocytes and stem cells drive skin aging through ROS, DNA damage, ...
Tag: SASP
Scientists Discover PTCHD4 as a Novel Driver of Cellular Aging and Age-Related Disease
Researchers have identified the little-studied transmembrane protein PTCHD4 as a novel regulator of cellular senescence whose deletion extends lifespan and ...
Zombie cells caught fueling bone loss as scientists map senescence in osteoporosis
A new review in Biogerontology argues that senescent cells and their inflammatory secretions act as a convergent, independently targetable driver ...
Scientists Rethink Neuronal Senescence as Brain Aging Markers Fail the Test
A new review argues that neurons can acquire senescence-like states in aging and neurodegenerative disease, but peripheral senescence markers cannot ...
Cannabidiol Eases Heart Failure Damage by Rejuvenating Aging Cells and Restoring Organelle Communication
New research in mice shows that cannabidiol reduces cardiac fibrosis and diastolic dysfunction in HFpEF by clearing senescent cells, suppressing ...
Old Immunosuppressant Drug Found to Kill Aging Cells and Block Cancer
Researchers found that the immunosuppressant cyclosporine A selectively kills senescent cells by triggering endoplasmic reticulum stress and paraptosis-like death, preventing ...
Nanoparticles Emerge as a Powerful New Weapon Against Cellular Aging
A comprehensive review in Biogerontology argues that engineered nanoparticles could overcome the solubility, stability, and targeting limitations of senolytic drugs, ...
Scientists Chart a Common Roadmap to Bring Senescence Medicine Into the Clinic
A consensus statement from the SENESCENCE2030 network published in Nature Aging outlines a roadmap for turning cellular senescence research into ...
Senescent Kidney Cells Build Inflammatory Niches That Senolytics Can Dissolve
Researchers have mapped how senescent kidney cells attract immune cells into localized inflammatory niches and shown that senolytic treatments can ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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