Senolytic Drugs and Aerobic Exercise Each Rejuvenate the Aging Mouse Heart
A nine-month study in mice shows that chronic senolytic treatment and aerobic exercise each reduce senescent cell markers in the ...
Tag: SASP
How Stressed Blood Flow and Metabolism Drive Ageing Arteries
A new review proposes that disturbed blood flow and metabolic stress converge to drive endothelial cell senescence, amplifying cardiometabolic vascular ...
Senolytic Drugs Show Promise Against Bone Loss Caused by Chemotherapy
A new mouse study shows that senolytic drugs targeting senescent cells can partially mitigate the bone loss and marrow fat ...
Vascular Receptor TLR4 Emerges as a Master Switch Between Vascular Aging and Targeted Senotherapeutics
A new review in Aging Cell positions endothelial TLR4 as a context-dependent molecular rheostat controlling vascular senescence, arguing that precision ...
Engineered Flavonoid Cousins of Fisetin Clear Senescent Cells and Boost Healthspan in Mice
Researchers engineered two fisetin-derived flavonoid analogs that kill senescent cells up to 27 times more potently than fisetin and reduce ...
Mini-GRID Radiotherapy Curbs Cellular Senescence While Keeping Its Anti-Tumor Punch in Glioma Cells
A preclinical study finds that spatially fractionated mini-GRID radiotherapy preserves the growth-inhibitory effect of radiation in glioma cells while markedly ...
Aging Eye Study Uncovers Molecular Cascade Behind Blinding Retinal Scarring
Researchers have identified a LAPTM5-WWP2-OPTN mitophagy cascade that drives retinal pigment epithelium senescence and subretinal fibrosis through cGAS-STING activation, with ...
Leaking Mitochondrial DNA Emerges as a Central Engine of Cellular Aging
A new review in Biogerontology argues that leaking mitochondrial DNA activates the cGAS-STING innate immune pathway in senescent cells, sustaining ...
T Cell-Engaging Antibody Clears Aging Cells in Mice and Monkeys, With Liver Enzymes as a Built-In Safety Gauge
A uPAR-targeting bispecific T-cell engager safely cleared senescent cells in aged mice and rhesus macaques, with serum liver enzymes serving ...
Ancient Herb Compound Purges Zombie Cells That Make Arteries Fragile
Researchers report that salvianolic acid A, a compound from Salvia miltiorrhiza, directly binds HSP90α to dismantle the AKT-PERK survival complex ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!