UV radiation boosts ribosome production in Fusarium mangiferae filaments
In the plant pathogen Fusarium mangiferae, ultraviolet C radiation significantly increases ribosome levels and translation capacity in filaments, and blocking ...
Tag: ribosome biogenesis
Integrative mapping of chloroplast rRNA modifications reveals conserved and lineage-specific features and stepwise modification during plastid ribosome biogenesis
An integrative Arabidopsis study mapped chloroplast rRNA modifications and linked stepwise modification during ribosome biogenesis to rRNA maturation, chloroplast ribosome ...
First-in-class NVL inhibitors starve tumors by blocking ribosome assembly
Researchers have developed the first selective inhibitors of the NVL ATPase, blocking 60S ribosomal subunit assembly to activate p53 and ...
Ribosome-Building Enzyme DIMT1 Emerges as a Pan-Cancer Biomarker and Gastric Cancer Drug Target
A comprehensive pan-cancer study identifies the ribosome biogenesis enzyme DIMT1 as a prognostic and immune-associated biomarker whose depletion suppresses gastric ...
Leishmania Parasites Rewire Their Genes to Survive Antimony Drug Attacks
New research reveals that Leishmania parasites survive antimony treatment through active transcriptome remodeling, a transient persister state that may pave ...
Fruit Fly Protein Xrp1 Guards the Genome Through Two Separate Tumor-Suppressing Pathways
A new PLOS Genetics study shows that the Drosophila protein Xrp1 protects genome integrity through both a p53-dependent DNA damage ...
Brain-Penetrating Acridine Drug JP-1302 Cripples Cancer Cells by Shutting Down Ribosome Factory
A brain-penetrating acridine compound originally developed as an adrenergic receptor antagonist potently shuts down RNA polymerase I transcription, degrades the ...
Splicing factor SRSF1 tunes nucleolar cap pH to rescue ribosome factories after stress
A new Nature Chemical Biology study shows that the splicing factor SRSF1 is recruited to dark nucleolar caps under stress, ...
Molecular Efficiency Decides Which Alpine Desert Plants Survive Warming Climates
A multi-year field experiment on the Qinghai-Xizang Plateau reveals that transcriptomic efficiency, not the magnitude of gene expression change, determines ...
Balanced mRNA and ribosome levels govern growth in eukaryotic cells
A new study in budding yeast suggests that one of biology’s most fundamental processes—cell growth—may be governed by a remarkably ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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