Scientists decode the hidden rules that steer brain cancer cell states
Two studies show glioblastoma cells follow predictable paths between states, and reprogramming a single regulator improved survival in mouse models.
Tag: reprogramming
Scientists propose turning pathogenic Klebsiella into an industrial secretion factory
A new review outlines how the secretion systems of the opportunistic pathogen Klebsiella quasipneumoniae might be detoxified and redirected for ...
Transient early-pluripotency treatment yields human iPSCs with stronger differentiation
A transient 4CL treatment during reprogramming yields human iPSCs with enhanced mesodermal, endodermal, and pancreatic differentiation capacity.
Gingival fibroblast-derived iPSCs show broad methylation convergence with residual somatic patterns
A methylation comparison of human gingival fibroblasts, their derived iPSCs and an embryonic stem-cell reference found broad pluripotent-state convergence alongside ...
Preclinical thyroid cancer study restores CAR-T target with targeted drugs
A preclinical Mayo Clinic study found that MAPK inhibitors restored TSHR on anaplastic thyroid cancer cells and improved tumor control ...
Ion Channel Axis KCNE3-KCNQ1 Drives Bone Repair Through Vessel and Energy Metabolism Coupling
A mouse study finds that the KCNE3-KCNQ1 potassium channel axis couples mitochondrial energy metabolism to vessel growth and bone formation, ...
Multi-lineage reprogramming and NOTCH-associated signaling remodeling characterize the aggressive biology of early-onset colorectal cancer
A seven-cohort single-cell atlas links early-onset colorectal cancer to coordinated epithelial, stromal and NOTCH-associated signaling changes.
Myeloid drugs rarely prove immune conversion in solid tumors
A 2026 narrative review finds that most myeloid-directed cancer programs show target activity without proving immune conversion and proposes a ...
MiR-145 emerges as a driver and biomarker of the fibrotic tumor microenvironment
A new study identifies miR-145 as a driver and biomarker of the fibrotic tumor microenvironment, linking NOTCH signaling, promoter hypomethylation, ...
Macrophage Metabolic Switch Could Heal Diabetic Wounds
A macrophage enzyme called transketolase emerges as a metabolic checkpoint controlling blood vessel regeneration in diabetic wounds, and a nanozyme ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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