Scavenger Receptor and TLR4 Team Up to Drive TGF-β1 and Tregs in Schistosomiasis
SR-A1 cooperates with TLR4 signaling in macrophages to drive TGF-β1 production, inducing regulatory T cells that reduce liver damage during ...
Tag: regulatory T cells
CD276 Blockade Slows Gastric Cancer and Boosts Anti-PD-1 Immunotherapy in Preclinical Study
Blocking the CD276 molecule slowed gastric cancer growth and, combined with anti-PD-1 therapy, produced the strongest tumor suppression and increased ...
Dendritic cells and regulatory T cells reinforce immunosuppression in pancreatic tumors
Single-cell and spatial profiling of pancreatic tumors reveals a reinforcing loop between mature dendritic cells and regulatory T cells, mediated ...
Immune Cells Turned Accomplices: How the Body’s Defenses Help Cancer Spread
A new narrative review in Frontiers in Oncology details how T cells, macrophages, neutrophils, B cells, NK cells, and dendritic ...
NF-κB/Atg5 Axis Linked to Treg Dysfunction in Kidney Antibody-Mediated Rejection
A new study identifies Atg5-dependent Treg regulation as a mechanistic link between Treg dysfunction and macrophage inflammation in kidney antibody-mediated ...
Fibroblasts That Show Tumors’ IDs May Be Shapeshifters, Not Fixed Subtypes
A new perspective argues that antigen-presenting fibroblasts in gastrointestinal tumors are reversible states whose immune role depends on unmeasured co-stimulatory ...
Baseline immune profiles are associated with positive outcomes in young children with a peanut allergy, enrolled in a randomised clinical trial for oral immunotherapy
A randomised trial in 49 peanut-allergic toddlers found that baseline immune cell profiles and peanut-specific IgE levels were associated with ...
Boosting the Body’s Own Muscle Repair Offers New Hope for Muscular Dystrophy
A new review argues that drugs enhancing the body's own muscle regeneration, exemplified by the approved HDAC inhibitor Givinostat, could ...
Two-pronged antibody depletes suppressive T cells and boosts antitumor immunity in mice
A new bispecific antibody targeting CCR8 and CD3 shrank breast, lung and colon tumors in mice and was well tolerated ...
Drug-loaded hydrogel triggers immune cells to rebuild bone in defects
A collagen hydrogel releasing a T cell-inducing drug enhanced bone regeneration in a rodent skull defect model.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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