Isoleucine and Valine, Not Leucine, Drive T Cell Proliferation Through c-Myc
A mouse study finds that isoleucine and valine, rather than leucine, sustain c-Myc expression and proliferation in activated CD8 T ...
Tag: Rapamycin
Collagen-Coated Rapamycin Liposomes Show Cartilage Repair Promise in Rats
A collagen-coated rapamycin liposome system preserved cartilage structure and showed no organ toxicity in a rat model of osteoarthritis.
Multi-omics study links autophagy and ER stress to PFOA toxicity in sperm precursor cells
A multi-omics study in GC-1 spermatogonial cells links PFOA exposure to altered autophagy, ER stress signaling and oxidative imbalance, with ...
mTORC1 may act as a transition switch in ME/CFS post-exertional malaise
A new review proposes mTORC1 as a transition switch linking mitochondrial dysfunction to post-exertional malaise in ME/CFS, while noting that ...
Rapamycin impairs viability and reshapes autophagy gene expression in Schistosoma mansoni
A laboratory study finds that rapamycin reduces the viability of both juvenile and adult Schistosoma mansoni and alters autophagy gene ...
Same Drug, Different Cells: Why mTOR Inhibition in Plaques Defies Simple Rules
A new review argues that mTOR's effects in atherosclerotic plaques depend on cell state, plaque niche, signalling complex and drug ...
Mouse aging-rate indicators could speed anti-aging drug screening
A systematic review of mouse longevity studies proposes 12 experimental aging rate indicators that could accelerate early screening of anti-aging ...
UV radiation boosts ribosome production in Fusarium mangiferae filaments
In the plant pathogen Fusarium mangiferae, ultraviolet C radiation significantly increases ribosome levels and translation capacity in filaments, and blocking ...
Scientists Uncover Hidden Protein Driver Behind Scarring Kidney Disease
New research reveals that the protein Annexin A1 drives kidney fibrosis by activating YAP signaling and suppressing autophagy in renal ...
Jonathan the 194-Year-Old Tortoise Reveals a Genetic Secret to Aging Slowly
A Vanderbilt-led team sequencing the genome and epigenome of Jonathan, a 194-year-old giant tortoise on St. Helena, found that promoters ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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