How Inflammaging Drives Heart Attacks in Older Adults—and Immunotherapy Hopes
A new review in Biogerontology links age-related chronic inflammation, cytokine dysregulation and cellular senescence to heightened heart attack risk in ...
Tag: pyroptosis
Nanomedicines Offer New Routes Past the Brain’s Defenses Against Drug-Resistant Tumours
A new review in Molecular Cancer details how five classes of nanomaterials could breach the blood–brain barrier and dismantle the ...
AI-Designed Gasdermins Programmed to Destroy Virus-Infected Cells
A Cell Research article examines how artificial intelligence-guided engineering of gasdermin pore-forming proteins could be harnessed to selectively eliminate virus-infected ...
Innate Immune Sensors in Focus: Structural Insights into Inflammasomes and PANoptosomes Open New Therapeutic Avenues
A Cell Research review synthesizes structural and mechanistic insights into inflammasomes and PANoptosomes, revealing how innate immune sensors assemble inflammatory ...
Arthritis Drug Diacerein Shows Surprising Power Against Deadly Brain Cancer
Researchers report that the osteoarthritis drug diacerein kills glioma cells by triggering caspase-3 and GSDME-mediated pyroptosis, revealing a new drug-repurposing ...
Blocking a Single Kinase May Steer Immune Cells Toward Safer Atherosclerotic Plaques
New research shows that removing protein kinase C delta reprograms macrophage metabolism to suppress inflammatory pyroptotic cell death and stabilize ...
NINJ1: The Membrane-Rupturing Protein That Decides How Cells Die and How Tumors Thrive
A new review in the Journal of Cancer Research and Clinical Oncology examines how the NINJ1 protein executes plasma membrane ...
Glycolytic Enzyme Accelerates ALS by Fueling Inflammatory Neuron Death
New research shows that loss of TDP-43 in ALS drives the glycolytic enzyme ALDOA to trigger inflammatory pyroptotic death of ...
Autophagy Protein AMBRA1 Unlocks NLRP3 Inflammasome Activation
Researchers have discovered that the autophagy protein AMBRA1 directly binds and allosterically opens the autoinhibited NLRP3 inflammasome, revealing a new ...
VALD-3 Triggers Pyroptosis in Triple-Negative Breast Cancer Through ROS/JNK/Bax Pathway
A synthetic compound derived from a family of molecules first described in the nineteenth century is emerging as a surprising ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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