Low Oxygen Turns Inflammatory Switch That Drives Oral Cancer Growth
New research in the British Journal of Cancer shows that oxygen-starved oral cancer cells activate an HMGB1-driven NLRP3 inflammasome pathway ...
Tag: pyroptosis
How Exercise Trains the Immune System to Fight Infection
New research in PLOS Pathogens reveals that exercise drives a protective metabolite pathway that pushes the NLRP3 inflammasome into a ...
Trojan Horse Inhibitors Slip Through Gasdermin Pores to Shut Down Pyroptosis
New research shows that gasdermin D pores formed during pyroptosis can admit selectively designed caspase inhibitors, allowing the inflammatory cell ...
Cell Death Signature in Gut Lining Predicts Inflammatory Bowel Disease Relapse
A new study shows that a necroptotic-to-apoptotic cell death axis in intestinal epithelial cells, driven by TNF and interferon gamma, ...
Dead Bacteria, Living Protection: Heat-Killed Probiotic Blocks Inflammatory Cell Death to Heal Stomach Ulcers
Heat-killed Bifidobacterium animalis subsp. lactis BB-12 protected mice from indomethacin-induced gastric ulcers as effectively as live probiotics and better than ...
A Common Amino Acid Throws a Molecular Wrench Into the Body’s Inflammation Machine
New research shows the dietary amino acid l-arginine directly binds the NLRP3 inflammasome and blocks its assembly, easing inflammatory and ...
The Amino Acid Arginine Emerges as a Brake on the NLRP3 Inflammasome
A Nature Metabolism commentary highlights new evidence that the amino acid l-arginine can inhibit activation of the NLRP3 inflammasome, raising ...
Overactive Inflammasome in Artery Muscle Cells Drives Dangerous Vessel Thickening in Mice
A new mouse study shows that hyperactive NLRP3 inflammasome signaling within vascular smooth muscle cells drives inflammation, pyroptosis, lipid accumulation, ...
Plant Compound Salvianolic Acid B Shields Heart Cells From Sugar-Driven Inflammatory Cell Death
New research shows that salvianolic acid B, a polyphenol from red sage, protects human heart muscle cells from high-glucose injury ...
Electron-Pumping Photosensitizer and Nanozyme Team Up to Kill Breast Cancer Cells Three Ways at Once
Researchers engineered a cyanine photosensitizer with a benzophenone electron-pumping group and loaded it into a pH-responsive, hyaluronic acid-coated iron nanozyme ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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