AlphaFold 3 Structures Can Guide T-Cell Receptor Engineering, With Caveats
A benchmark of 438 TCR–pMHC mutations shows experimental structures remain the best input for binding-affinity predictors, while AlphaFold 3 mutant ...
Tag: protein structure prediction
Computer models point to a proline enzyme and a mystery scaffold in a salt-tolerant plant microbe
Computational modelling of two hypothetical proteins from Kosakonia cowanii F52 predicts an NAD(P)-binding Rossmann-fold oxidoreductase linked to proline metabolism and ...
New benchmark exposes persistent weaknesses in AI molecular design tools
A new benchmark called MolGenBench evaluated 17 generative models for structure-based drug design and found persistent weaknesses in producing reliable ...
AI advances BMP4 research, but experimental validation remains essential
A 2026 review finds that AI has accelerated BMP4 structure modeling, multi-omics analysis and prognostic research while emphasizing that experimental ...
Fusion Platform Recovers Previously Unproducible Bacterial Toxins
A modular toxin–immunity fusion system enables the production, purification and functional analysis of highly toxic bacterial proteins that conventional recombinant-expression ...
AI Protein Models Guide Cheaper, Sharper Antibody Tests for Crop Viruses
Researchers used AlphaFold3 structure predictions to select viral coat protein epitopes, producing low-cost polyclonal antibodies with markedly better specificity for ...
A Single-Celled Parasite Carries More Rab Genes Than Humans, and AlphaFold3 Reveals Why
A computational study reveals that the parasitic amoeba Entamoeba histolytica encodes more than ninety Rab GTPase genes whose predicted structures ...
Hybrid docking-assembly algorithm cracks the structures of giant protein complexes
A new hybrid framework called HDOCK-Multimer combines protein-protein docking with combinatorial assembly to predict the structures of large protein complexes ...
Lightweight AI Tool Outsmarts Deep Learning at Spotting Disordered Proteins
A researcher at IIIT Allahabad has developed IDP-T5CKNN, a lightweight protein language model method that outperforms more than 20 existing ...
AI Can Predict Protein Structures Brilliantly, But a New Review Asks Whether Biology Can Trust It
A systematic review of 38 studies finds that protein language models excel on benchmarks but largely lack experimental validation, prompting ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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