Misfolded Proteins, Inflammasomes and the Spreading of ASC Specks in Neurodegeneration
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...
Tag: protein misfolding
Two SOD1 Aggregate Strains Differ in How Fast ALS-Like Disease Spreads to the CNS
In SOD1G85R mice, sciatic nerve inoculation with two distinct SOD1 aggregate strains transmitted templated aggregation to the CNS, with strain ...
Lab Protocol Amplifies Prions from Deer and Other Animals to Detect Chronic Wasting Disease
Researchers have published an updated laboratory protocol detailing how the protein misfolding cyclic amplification technique can replicate chronic wasting disease ...
Johns Hopkins-led protein-misfolding research protocol receives up to $52.1 million
A Johns Hopkins Medicine-led protocol will use up to $52.1 million in ARPA-H funding to study protein misfolding and develop ...
Scientists Receive Up to $51.7 Million to Predict Protein Misfolding Before Disease Begins
A co-led Buck Institute and Georgetown University team has won an ARPA-H award of up to $51.7 million to predict ...
AI Meets Living Cells in $28.6 Million Bid to Predict Protein Misfolding Before Disease Strikes
A Stowers Institute scientist will help lead a $28.6 million ARPA-H effort to generate billions of protein aggregation measurements and ...
Misfolded Proteins May Explain a Hidden Share of Inherited Deafness
A large-scale computational study finds that protein misfolding may underlie a substantial share of hereditary hearing loss, reclassifying tens of ...
How one assay turned prion detection into a revolution across neurodegeneration
A new review in Acta Neuropathologica chronicles how Byron Caughey's development of the RT-QuIC assay revolutionized prion detection and seeded ...
Four Decades of Hunting the Misfolded Protein: How Prion Research Grew Into a Blueprint for Neurodegenerative Drug Design
A new review in Acta Neuropathologica chronicles four decades of Byron Caughey's pioneering work on prion disease inhibitors, from infrared ...
Considerations for Combination Therapies Aiming Disease Modification in Parkinson’s
A new analysis published in npj Parkinson’s Disease considers how combination therapies might better slow or modify Parkinson’s disease—an approach ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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