Tag: protein design

Researchers used RFdiffusion, ProteinMPNN, and molecular dynamics to design novel protein binders against the human sweet taste receptor TAS1R2, creating ...

Researchers have computationally designed artificial cysteine proteases from scratch that cleave peptide bonds with rate enhancements of up to ten ...

Researchers have used AI-driven protein design to create entirely new zinc-dependent proteases that cleave disease-linked proteins such as TDP-43 and ...

When SARS-CoV-2 first swept across the globe in early 2020, the pharmaceutical world faced a brutal mismatch: conventional vaccine and ...

The new generative AI system RFdiffusion3 designs proteins and nucleic acids atom by atom, producing functional enzymes and RNA molecules ...

Researchers propose a closed-loop framework that unites AI-driven sequence design, molecular dynamics simulation, and experimental validation to rationally engineer high-affinity, ...

Researchers combined structure-guided protein design with cis-regulatory editing at the native HPPD locus to create elite herbicide-tolerance alleles in rice ...

Researchers have combined structure-guided protein design with cis-regulatory enhancer insertion to create rice and wheat plants that tolerate herbicide doses ...

A team at Nanjing Medical University used RFdiffusion to design a CLDN18.2-targeting T-cell engager for gastric cancer and showed that ...

A new review argues that insulin receptor signaling is a programmable, context-dependent network that engineered mimetics can selectively retune across ...