EP300 Degradation and AKT Inhibition Slow Osteosarcoma in Preclinical Models
A PROTAC that degrades EP300 combined with AKT inhibition slowed tumor growth and extended survival in patient-derived osteosarcoma mouse models, ...
Tag: protein degradation
MG53 degrades AMPKα and suppresses bladder cancer in preclinical models
Preclinical tissue, cell, and xenograft experiments found that MG53 promoted AMPKα degradation, reduced glycolytic metabolism and tumor growth, and increased ...
Braised chicken loses its aroma first: scientists trace six months of flavor decay down to four volatile markers
A six-month storage study of Dezhou braised chicken combining sensory panels, electronic tongue and nose, and GC–IMS identifies octanal, diethyl ...
Beyond the On-Off Switch: Chemical Tags on KRAS Reshape Cancer Drug Design
A new review in Advanced Cancer Research details how post-translational modifications regulate KRAS localization, activity, stability, and degradation, opening fresh ...
How HIV-1’s Vpr Protein Hijacks a Human Degradation Machine to Destroy Diverse Targets
New cryo-EM structures reveal how the HIV-1 protein Vpr reshapes the human CRL4(VprBP) E3 ligase to degrade host substrates of ...
Engineered Protein Breakdown Supercharges Drug-Free Selection of High-Producing CHO Cells
Researchers at Inha University engineered destabilized glutamine synthetase variants that dramatically increase selection stringency in CHO cells, enabling drug-free isolation ...
How Cells Build Their Protein Shredder: New Rules of Proteasome Biogenesis
A new review argues that mammalian cells regulate the construction of their proteasomes through layered transcriptional networks and assembly pathways, ...
Targeting the Ubiquitin Machinery to Rewire KRAS-Driven Cancers
A new review argues that deubiquitinase enzymes within the ubiquitin-proteasome system offer promising therapeutic angles against KRAS-driven cancers that resist ...
E. coli cells race to rebuild their proteins in the first hours of starvation
New single-cell microscopy reveals that E. coli immediately halts growth when carbon runs out and uses the first hours of ...
Plant Nanoparticles Deliver a Protein-Degrading Drug That Strikes Colorectal Cancer
Scientists have engineered a PROTAC molecule that destroys the RARα protein and delivered it via Polygonatum sibiricum exosome-like nanoparticles, markedly ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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