PROTACs Recruit the Ubiquitin-Proteasome System to Degrade Breast Cancer Proteins
Breast cancer remains the most frequently diagnosed malignancy and a leading cause of cancer death among women worldwide, with more ...
Tag: PROTACs
Next-Generation CRBN Modulators Show Promise Against IMiD Resistance in PROTAC Therapy
A new computational study suggests that next-generation CRBN E3 ligase modulators, particularly CC-885, may hold the key to overcoming mutation-driven ...
Light-Activated Molecular Degraders Put Protein Destruction Under Remote Control
Chemists have developed ruthenium-based photocaged PROTACs, called RuPHOTACs, that can be switched on with low-energy red light to selectively degrade ...
How Liquid Droplets Inside Cells May Drive Cancer—and What Drugs Could Do About It
A new review in Molecular Cancer provides a rigorous framework for how liquid–liquid phase separation drives cancer biology and evaluates ...
PROTACs Move From Lab Concept to Clinical Reality in Targeted Protein Degradation
A new comprehensive review in Discover Chemistry details how PROTACs have evolved from a mechanistic concept into clinically advanced degraders ...
Dual PROTACs Close In on Two Disease Proteins at Once
A new review in Molecular Diversity charts the rapid rise of dual PROTACs, single molecules engineered to destroy two disease-driving ...
Advances and Challenges in Targeting BET Proteins in Solid Tumors
BET proteins, particularly BRD4, have emerged as pivotal drivers of oncogenic transcription in various solid tumors, presenting a promising but ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!