NIH-funded study probes prenatal vaping and offspring antiviral immunity
A five-year NIH-funded Wayne State study will use preclinical models to investigate how e-cigarette components during pregnancy affect fetal lung ...
Tag: preclinical models
Smart bomb combination curbs metastatic triple-negative breast cancer in models
A CD276-targeted antibody-drug conjugate combined with mitochondrial-disrupting gene therapy outperformed either treatment alone in two preclinical models of metastatic triple-negative ...
Chronic Lung Infection Surprisingly Sustains Gene Therapy Expression in Cystic Fibrosis Rat Lungs
New research in cystic fibrosis rats shows that chronic Pseudomonas aeruginosa lung infection does not hinder lentiviral vector gene transfer ...
Nanoparticles may carry CRISPR gene editing into infant neuroblastoma
Infant neuroblastoma is one of the most clinically paradoxical cancers in medicine. Diagnosed during the first year of life, it ...
3D-Printed Melanoma Models Promise Better Drug Tests but Face an Analysis Bottleneck
A new perspective highlights that while 3D bioprinted melanoma models closely mimic real tumors, outdated two-dimensional analysis methods are undermining ...
Childhood Brain Tumor Study Exposes KDM2B as a Treatable Weak Spot in High-Risk Medulloblastoma
A comprehensive epigenetic analysis led by St. Jude and KiTZ identified the chromatin regulator KDM2B as an essential, selective dependency ...
Brain Stimulation for Depression Works Differently Depending on the Brain It Hits, Rat Study Finds
A new rat study shows that rTMS for depression recruits different behavioral, hormonal, and molecular adaptations depending on whether the ...
Bridging the Lab and the Clinic: Why Addiction Science Needs Translational Research
A new commentary in the Journal of Translational Medicine argues that refined animal models and emerging tools like rodent fMRI ...
New Antibody Targets BAMBI to Rewire Immune Cells in Psoriatic Arthritis
Spanish researchers have developed a humanized monoclonal antibody, hB101.37, that inhibits the BAMBI pseudoreceptor and rebalances T cell immunity, showing ...
Stem Cells Reshape the Gut Microbiome, but a Blood Pressure Cure Remains Elusive
A systematic review of 31 preclinical studies finds that mesenchymal stem cell therapy can modulate gut microbiota across multiple disease ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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