Rare KCNJ6 Mutation Causes Severe GIRK2 Channel Gain of Function in Lab Tests
Researchers discovered that a rare KCNJ6 mutation linked to mild Keppen-Lubinsky syndrome paradoxically produces severe GIRK2 channel gain of function ...
Tag: potassium channels
Dysregulated Potassium Channels Reveal Potential Drug Repurposing Candidates for Long COVID
A transcriptomic meta-analysis reveals dysregulated potassium channels in long COVID patients, highlighting existing approved medications as potential candidates for repurposing.
TALK Potassium Channels Emerge as Hidden Regulators of Insulin Secretion
A new review links the TALK-1 and TALK-2 potassium channels to β-cell calcium handling and insulin secretion while cautioning that ...
Passion Fruit Shows Blood Pressure Promise, but Human Evidence Remains Thin
A systematic review of eight studies finds consistent blood pressure-lowering signals from Passiflora edulis across animal models and two small ...
Potassium channel gene KCNJ11 predicts glioma survival and chemotherapy response
A 19-year single-center study of 516 glioma patients, validated in three public cohorts, shows that high KCNJ11 mRNA expression marks ...
BK Channel Models Link Higher Conductance to Precise Neuronal Spike Timing
Evolutionary and computational models suggest that higher BK potassium-channel conductance may ease calcium-dependent activation limits and improve the precision of ...
Molecular dynamics and cell experiments identify third Kv4.3–KChIP1 interface
Molecular dynamics and electrophysiology experiments identify a salt-bridge-rich third interface that stabilizes Kv4.3–KChIP1 complexes and supports potassium-channel tetramerization.
Missing Immune Receptor Silences the Ear’s Nerve Cells and Drives Hearing Loss
A new study shows that the chemokine receptor CXCR2, long associated with inflammation, is essential for hearing because its loss ...
Hormone Meets Channel: Leptin Emerges as a Bridge Between Brain Development and Metabolism
New research in iScience shows that the hormone leptin, the potassium channel Kcnb1, and integrins form a tripartite brain complex ...
Hidden Protein Interface in Potassium Channels Revealed as a Master Switch for Sleep
A forward genetic screen in worms reveals that a conserved interface between cyclic nucleotide-binding domains restrains KCNH potassium channel activation, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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