Tag: post-translational modifications

A new review synthesizes how phosphorylation, ubiquitination, methylation, SUMOylation and O-GlcNAcylation form an interconnected network that controls the mitotic kinase ...

A new review maps how metabolite-driven protein modifications such as lactylation, O-GlcNAcylation and succinylation may link the disc's harsh metabolic ...

A review in Acta Neuropathologica Communications describes how aberrant liquid-liquid phase separation may drive glioblastoma progression and therapy resistance, and ...

A review finds that protein modifications regulate immune inflammation and epithelial barrier dysfunction in ulcerative colitis through mechanisms that remain ...

A review maps the neddylation pathway, its non-Cullin substrates and small-molecule inhibitors, including two NAE inhibitors that have entered clinical ...

A new review reveals how the tumor suppressor and deubiquitinating enzyme CYLD is switched on and off by phosphorylation, ubiquitination, ...

A new BMC Medicine review maps how post-translational modifications act as a networked control layer that gates, amplifies, and dampens ...

A new multi-omics and machine learning study identifies the USP18 gene as a hub linking isonicotinylation and mast cell activity ...

A new review in Advanced Cancer Research details how post-translational modifications regulate KRAS localization, activity, stability, and degradation, opening fresh ...

A new review in the Journal of Translational Medicine reframes tau phosphorylation as a dynamic hub within a multi-scale network ...