Single ubiquitin tags on non-histone proteins shape health and disease
A comprehensive review in Cellular and Molecular Life Sciences maps how single ubiquitin marks on non-histone proteins regulate DNA repair, ...
Tag: post-translational modification
Two protein tags talk to each other and steer cancer’s fate
A new review in Genes & Diseases maps how arginine methylation and ubiquitination continuously regulate each other to influence cancer ...
Hidden Chemical Tag on Zika Protein Revealed as Key to Viral Secretion
Researchers at Radboud University Medical Center report that prolyl hydroxylation of Zika virus NS1 is essential for the protein's maturation ...
Protein Glutamylation Emerges as a Versatile Signaling Mechanism Beyond the Cytoskeleton
A new review in Med Research redefines protein glutamylation as a versatile signaling-related post-translational modification with roles in immunity, development, ...
Machine Learning Links a Rare Protein Modification and Mast Cells to Duchenne Muscular Dystrophy
A new multi-omics and machine learning study identifies the USP18 gene as a hub linking isonicotinylation and mast cell activity ...
Two Molecular Machines, One Cancer Engine: How Deubiquitinases and m6A RNA Tags Talk to Each Other
A new review in Molecular Cancer maps the bidirectional crosstalk between deubiquitinases and m6A RNA modification, revealing a coupled regulatory ...
The Phosphatase Switch: How PP2Acα Emerges as a Drug Target for Inflammatory Bowel Disease
A new review argues that the phosphorylation-dephosphorylation balance controlled largely by the phosphatase PP2Acα acts as a master switch in ...
Sticky Tags on a Viral Enzyme: SUMOylation Steers Herpesvirus Thymidine Kinase Into Neurons
Researchers report that SUMOylation of pseudorabies virus thymidine kinase at two lysine residues controls the enzyme's nuclear localization, enabling efficient ...
Bacterial Enzyme KwwB Forges Unusual Peptide Cross-Links and Shrugs Off Leader Mutations
Researchers have shown that the P450 cyptide synthase KwwB can install a non-native Tyr-C3–Trp-N1 cross-link on engineered precursor peptides and ...
Cell cycle clock controls RNA methylation through a hidden ubiquitin code
A new Nature Chemical Biology study reveals that the ubiquitin ligase RLIM tags the m6A writer METTL14 with noncanonical K27-linked ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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