KRAS Phosphorylation Drives Colorectal Cancer Invasion by Boosting Cathepsin B Secretion
Phosphorylation of KRAS at Ser181 promotes invasion and metastasis in colorectal cancer cells by regulating the secretion of lysosomal proteins, ...
Tag: post-translational modification
How HPV rewires sugar chemistry in cervical cancer cells
A new review finds that O-GlcNAcylation links HPV-driven metabolic demand to growth and survival pathways in cervical cancer, but no ...
FAIMS Boosts Detection of Homocysteine-Modified Proteins in Mouse Tissues
A new study shows that FAIMS gas-phase fractionation increases detection of N-homocysteinylated peptides and proteins in mouse liver and brain ...
Hidden Enzymes That Erase Protein Palmitoylation Emerge as Disease Drivers
A new review maps how ABHD enzymes regulate the reversible lipid modification S-palmitoylation and shape cancer, neurodegeneration, antiviral immunity and ...
Sugar Tag on ASGR1 Protein Curbs Deadly Heart Damage in Sepsis
A sugar modification of the ASGR1 protein reduces septic heart injury in mice by blocking ZBP1-driven PANoptosis, according to a ...
Lactate tags EZH2 protein to worsen sepsis lung injury in mice
A new study in mice and human endothelial cells shows that lactate-driven EZH2 lactylation at lysines 30 and 406 promotes ...
Fungal Enzyme Modification Controls Purine Metabolism in Verticillium Wilt
Researchers found that the S-acyltransferase VdERF2 modifies the purine metabolism enzyme VdHIUH in Verticillium dahliae, linking protein fatty-acylation to fungal ...
Hidden Protein Shield Helps Lung Tumors Survive Osimertinib Treatment
A new study shows that ZNF593-driven SUMOylation stabilizes the stress-responsive protein ANKRD1, which activates MERTK-AKT survival signaling and promotes acquired ...
Blood RNA markers illuminate protein-modification networks in heart attacks
A transcriptomic study identified GABARAPL1, PELI1 and NLRP3 as elevated blood RNA markers associated with acute myocardial infarction, while highlighting ...
Protein acylation in cancer: from regulatory networks to precision therapeutics
A peer-reviewed review examines protein acylation as a link among cancer metabolism, tumor plasticity, therapeutic resistance and proposed biomarker-guided treatment ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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