How Infection Signals Push Kidney Filter Cells Into Leaks, Damage, and Cell Death
New research shows that sustained activation of the innate immune receptor TLR4 in podocytes triggers a reversible leak in the ...
Tag: podocytes
Inflammatory Fatty Acid Drains Kidney Cells’ Energy Supply, Worsening Podocyte Damage
New research shows that arachidonic acid released during infection worsens podocyte kidney injury by disrupting PKM2-linked glycolytic metabolism and mitochondrial ...
Rare Kidney Disease Case: Monotypic IgG1-Lambda Fibrillary Glomerulonephritis Linked to Rheumatoid Arthritis
Czech physicians report the first confirmed case of DNAJB9-positive monotypic IgG1-lambda fibrillary glomerulonephritis in a rheumatoid arthritis patient without any ...
Scientists Discover a Lipid-Gated Calcium Channel That Drives Diabetic Kidney Damage
A new study identifies a ceramide-gated Calhm2 calcium influx pathway, driven by Aebp1, that injures podocytes in diabetic kidney disease ...
RNA Chemical Tag Emerges as Hidden Driver of Kidney Damage in Diabetes
A new study shows that the RNA demethylase FTO stabilizes EGR1 mRNA through m6A modification, activating a STING1-driven inflammatory cascade ...
Nerve-Linked Receptor Shields Kidney Filters in Sepsis, Study Finds
Activating the alpha-7 nicotinic acetylcholine receptor directly protects podocytes and preserves the kidney's filtration barrier during sepsis-associated acute kidney injury, ...
RNA-Binding Protein PTBP3 Drives Kidney Scarring in Diabetes, Study Finds
Researchers at Harbin Medical University report that the RNA-binding protein PTBP3 stabilizes SMAD3 mRNA and drives podocyte epithelial-to-mesenchymal transition, and ...
Forcing Kidney Cells to Divide Reveals a Hard Limit on Glomerular Growth
A transgenic mouse study shows that SV40T-induced podocyte proliferation, even during embryonic development, fails to enlarge glomeruli because surplus cells ...
Kidney Cells Caught Dispatching Exosomes That Ignite Immune Attack in Nephrotic Syndrome
New research shows that injured kidney podocytes release exosomes carrying MHC-I antigen-presenting machinery that activates CD8-positive T cells directly and, ...
Proteasome Inhibition Eases Proteinuria in Mice With Faulty Kidney Filtration Genes
Blocking the proteasome reduces protein leakage in the urine of mice carrying dysfunctional Lmx1b LIM domains, pointing to a new ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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