Benchmark of 18 methods reveals limits of inferring microbial interactions from 16S count data
A benchmark of 18 co-occurrence network inference methods on synthetic 16S rDNA-seq data finds they perform reliably only under restricted, ...
Tag: PLOS Computational Biology
Real-time calibrated models could have sharpened pandemic decision support in England
Researchers propose a real-time calibration approach that embeds model discrepancy into infectious disease models to support pandemic policy decisions.
New computational framework predicts whether engineered microbial traits survive evolution
A new computational framework called TRAEV predicts whether engineered metabolic traits in microbial strains will persist under adaptive evolution in ...
Scientists map ten design-thinking rules for pivoting careers out of the lab
Two former STEM postdocs publish a design-thinking framework of ten rules for navigating a scientific career pivot, centered on emotional ...
Thirteen practical tips to improve bacteriophage genome annotation
Researchers have published a set of thirteen practical guidelines designed to help scientists annotate bacteriophage genomes accurately and prevent the ...
Ten Simple Rules Could Turn Genomics Into Everyday Medicine Across the Global South
A new PLOS Computational Biology perspective distills lessons from Global South capacity-building initiatives into ten rules for making genomic sequencing ...
New Toolkit Puts Simulated Neural Circuits to the Test
The central premise behind the Computation-through-Dynamics Toolkit rests on a conceptual shift that has been gaining momentum in systems neuroscience ...
Targeting Malaria Interventions by Geography Could Stretch Scarce Health Budgets
A spatially explicit model of malaria transmission in southeastern Madagascar shows that community-based interventions targeted by geography can match district-wide ...
Platelet Receptors Reveal Surprising Mechanical Differences That Could Shape Blood Clot Stability
New simulations reveal that alternative extracellular arrangements of the platelet receptors GPVI and CLEC-2 differ dramatically in their resistance to ...
Cell Shape Holds the Key to Bacterial Power Struggles, Simulations Show
Agent-based simulations reveal that bacterial cell shape determines whether competing populations in confined channels fixate or coexist, with sphere-like cells ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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