Tag: PGC-1α

Researchers have identified DDX49 as a driver of colorectal cancer progression that remodels mitochondrial oxidative phosphorylation by stabilizing PGC-1α.

A study in mouse and cell models reveals that astrocytic phosphodiesterase 5 disrupts bidirectional mitochondrial transfer and biogenesis between astrocytes ...

A rat and cell study finds empagliflozin eased isoproterenol-induced myocardial injury through PGC-1α-driven mitochondrial biogenesis and fatty acid utilization.

In diabetic rats, oral papain supplementation improved renal bioenergetic, antioxidant and inflammatory markers and raised PGC-1α gene expression, performing comparably ...

A zebrafish study shows that the ATP receptor P2RY11 sustains macrophage mitochondrial function through the SIRT1–PGC-1α axis and is required ...

A new review argues mitochondria act as mechanometabolic conductors of cancer metastasis while warning that shared peroxisomal machinery complicates drug ...

A 2026 mechanistic review links mitochondrial dysfunction with oxidative damage, altered NAD+-dependent signaling and disturbed communication among organelles during aging.

A new rat study shows that glycosides from the desert plant Cistanche reverse sleep deprivation-induced cognitive decline by activating the ...

New research shows that astrocytes carrying the C9ORF72 mutation disrupt mitochondrial transport in motor neurons through a contact-dependent bioenergetic mechanism ...

A new study shows that exosomes released by tumor-associated macrophages carry PD-L1 that reprograms the metabolism of CD8-positive T cells, ...