Macrophage Exosomes Disarm Immune Cells and Fuel Ovarian Cancer Spread
A new study shows that exosomes released by tumor-associated macrophages carry PD-L1 that reprograms the metabolism of CD8-positive T cells, ...
Tag: PGC-1α
Vitamin-Derived Molecule Shows First Signs of Treating Mitochondrial DNA Disease in Humans
A four-week trial of nicotinamide riboside in eight patients with mitochondrial DNA disease shows the first human evidence of molecular ...
Threaded Microneedles Deliver mRNA and Drugs to Precise Skin Layers
A modular threaded microneedle system delivers a senescence-fighting hydrogel to the dermis and metabolism-restoring mRNA nanoparticles to subcutaneous fat, reversing ...
Exercise Hormone Irisin Reveals a Complete Molecular Route From Muscle to Brain Protection in Alzheimer’s Disease
A new review in Biogerontology maps the complete molecular cascade by which the exercise hormone irisin travels from skeletal muscle ...
Plant Compound Syringaresinol Fires Up Muscle Hormone Irisin to Fight Weight Gain
New research shows the plant lignan syringaresinol activates the skeletal muscle SIRT1–PGC-1α–FNDC5/irisin axis in cells and high-fat-diet-fed mice, reducing weight ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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