RNA Editing Enzyme ADAR1 Emerges as Key Switch That Turns Cold Bladder Tumors Hot
Researchers found that inhibiting the RNA editing enzyme ADAR1 reprograms the immunosuppressive tumor microenvironment of bladder cancer and sensitizes it ...
Tag: PD-L1
Where does the immune pressure go? New framework explains immunotherapy resistance
A new Molecular Cancer review proposes immune-pressure redistribution as a unifying framework explaining why patients resist PD-1/PD-L1 blockade and how ...
Antibody-Drug Combination Falls Short in First-Line PD-L1-High Metastatic Lung Cancer Trial
The Phase 3 EVOKE-03/KEYNOTE-D46 trial found that sacituzumab govitecan plus pembrolizumab did not significantly improve progression-free or overall survival compared ...
Bispecific Antibody Meets Antibody-Drug Conjugate in Promising Small Cell Lung Cancer Trial
First clinical data from the Phase 1b/2 BNT324-01 trial show that the investigational combination of pumitamig and elfetabart drozuntecan achieved ...
ROS1 Fusion Subtype Shapes Survival in Advanced Lung Cancer, Real-World Data Show
A real-world study of 55 patients with advanced ROS1-rearranged non-small cell lung cancer shows that fusion subtype, PD-L1 expression and ...
Radium-223 Therapy Lowers PD-L1 in Prostate Cancer Bone Metastases, PET Study Shows
A prospective imaging study shows that radium-223 significantly reduces PD-L1 expression and depletes immune cells in prostate cancer bone metastases, ...
PET Imaging Reveals Whether Immunotherapy Drugs Actually Reach Their Tumour Targets
Researchers are using PD-L1-targeted PET/CT imaging to directly visualise whether the immunotherapy drug atezolizumab saturates its target in tumours, offering ...
METTL3 Emerges as a Molecular Hub Driving Tumor Immune Escape
A new review in the Journal of Translational Medicine details how the RNA methyltransferase METTL3 drives tumor immune escape through ...
PD-L1 Emerges as Key Survival Marker in Aggressive Canine Gastric Cancer
A full-thickness biopsy study of 40 dogs reveals that PD-L1 expression, rather than conventional histological features, is the strongest predictor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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