Tag: patient-derived organoids

Targeting casein kinase II alongside MEK signaling suppresses tumor growth and depletes cancer stem cells in metastatic colorectal cancer organoids.

Patient-derived gallbladder cancer organoids faithfully reproduced tumor genetics and showed drug sensitivities that tracked with patient survival in a preliminary ...

A patient-derived organ-on-a-chip platform grown from colorectal tumor tissue reproduced chemotherapy sensitivity profiles across eight patients and showed early, preliminary ...

A newly published consensus standard defines unified workflows, validation criteria and drug testing protocols for breast cancer organoids grown from ...

Organoid and clinical single-cell data link a DHX58-positive, CD62L-positive stem-like T-cell state to immune checkpoint blockade responsiveness in gastric cancer.

A long noncoding RNA called CYP4A22-AS1 promotes radioresistance in cervical adenocarcinoma by shuttling YBX1 into the nucleus to activate the ...

A gemcitabine-modified tumor-suppressor microRNA called Gem-miR-15a overcame 5-FU and oxaliplatin resistance in preclinical colorectal cancer models with low-nanomolar potency and ...

New research shows that inhibiting the ERG protein, overproduced in about half of prostate cancers, selectively impairs DNA double-strand break ...

A preclinical study finds that tubocapsenolide A inhibits PLK1, disrupting ESCRT-mediated damage clearance and restoring oxaliplatin sensitivity in resistant colorectal ...

A clonal DNA barcoding platform pools organoids from many colorectal cancer patients in one dish, tracking drug sensitivity through barcode ...