Worms Carry a Hidden Defense Against a Troubling Class of Drugs
New research reveals that the nematode Caenorhabditis elegans deploys a dedicated genetic defense system against cationic amphiphilic drugs, a finding ...
Tag: P-glycoprotein
Bioprinted Blood–Brain–Tumor Barrier Spheroids Put a ROS-Producing Ruthenium Drug to the Test Against Glioblastoma
Researchers built a 3D bioprinted blood–brain–tumor barrier spheroid that self-organizes into barrier and tumor layers and showed that a ROS-producing ...
Injectable Gel Turns Old Blood Pressure Drug Into Breast Cancer Ally Against Doxorubicin Resistance
Researchers have developed a thermoresponsive injectable gel that co-delivers doxorubicin with reserpine to block P-glycoprotein and CD44, overcoming multidrug resistance ...
Nanocarrier With Built-In Efflux Blocker Lifts Luteolin Absorption 29-Fold
Researchers engineered a TPGS-based self-microemulsifying delivery system that boosts luteolin's oral bioavailability 29-fold by simultaneously improving solubility, uptake and P-glycoprotein ...
Red Blood Cell Hitchhiking Delivers Oxygen and Paclitaxel to Crush Drug-Resistant Breast Cancer Metastases
Scientists have engineered red blood cell-hitchhiking liposomes that co-deliver hemoglobin and paclitaxel to lung metastases, reversing hypoxia-driven drug resistance and ...
Herbal Remedies Quietly Reshape Blood Thinner Levels in Healthy Volunteers
A clinical trial finds that the traditional Korean formulations Bojungikgitang and Cheongsanggyeontongtang substantially raise or lower edoxaban exposure in healthy ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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