Alkyl amines join the substitution toolbox as chemists strip nitrogen to forge carbon bonds
A Nature Synthesis study reports a deaminative nucleophilic substitution platform that converts alkyl amines into direct alkylation reagents for forging ...
Tag: organic synthesis
Aliquat 336 Catalyst Streamlines Regioselective Synthesis of Trifluoromethylpyrazoles
Chemists report two simplified routes to trifluoromethylpyrazoles, including a one-hour Aliquat 336-catalyzed coupling that avoids major side products.
Organic Pigment Derivative Powers Stable Light-Driven Sulfoxide Synthesis
Chemists report a soluble quinacridone photocatalyst that oxidizes sulfides to sulfoxides with oxygen under green light at 0.1 mol percent ...
New Indole–Benzimidazole Hybrids Built Through Optimized Multistep Synthesis
Chemists report a scalable multistep synthesis of indole–benzimidazole–piperazine carboxamide hybrids, optimized bond by bond and computationally profiled without claims of ...
Iridium Catalyst Achieves Elusive para-C–H Activation of Free Aromatic Carboxylic Acids
An iridium catalytic system using multiple noncovalent interactions enables para-C–H activation and borylation of free aromatic carboxylic acids without directing ...
Iron photocatalysis enables carbon-carbon bond formation
Rice University researchers used iron, sulfur, purple light and carboxylic acids to enable carbon-carbon bond formation through anti-Markovnikov alkene hydroalkylation.
Laccase review maps oxygen-driven routes to greener organic synthesis
A review of laccase catalysis shows how oxygen-driven enzymes can support greener oxidation, coupling, cyclization and polymerization reactions when enzyme, ...
Robots and Light Power KAIST’s Round-the-Clock Unmanned Drug Synthesis Platform
KAIST chemists have built an automated platform that combines robots, continuous-flow chemistry and visible light to synthesize drug candidate compounds ...
Single carbon atom joins flat molecules into rigid 3D spirocycles
Researchers at The University of Osaka have developed a rhodium-catalyzed reaction that uses a single carbon atom from a PINC ...
Chemists Build a Giant Molecular Screw That Glows in Circularly Polarized Light
Chemists in Tokyo have achieved the enantioselective synthesis of a giant π-extended carbohelicene using sequence-controlled quadruple cycloadditions, yielding an all-carbon ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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