REV-ERBβ emerges as a non-redundant brake on TH17-driven inflammation
New research reveals that the circadian nuclear receptor REV-ERBβ acts as a distinct, non-redundant negative regulator of pro-inflammatory TH17 cell ...
Tag: nuclear receptor
Parasitic Worm’s Molecular Switch Reveals How It Adapts to Its Rat Host
Researchers have identified the nuclear receptor AcNR1F as a ligand-activated molecular switch that regulates cuticle remodeling, development, and reproduction in ...
Silkworm Study Reveals Ancient Receptor Mechanism Behind Insect Skin Patterns
Researchers show that the ligand-independent nuclear receptor BmERR uses its AF-2 domain to recruit the coactivator PPRC1 and control melanin-driven ...
Bile Acid Sensor FXR Drives Liver Regeneration by Rebuilding Its Immune Cell Army
New research shows that the bile acid receptor FXR coordinates monocyte recruitment and Kupffer cell proliferation through CCR2 and CSF1/PI3K/Akt ...
Copper Overload Silences a Key Liver Fat Gene, Pushing Cells Into Ferroptosis in Wilson Disease
New research shows that copper accumulation in Wilson disease shuts down the PPARα–FABP1 fat-handling axis in hepatocytes, sensitizing them to ...
Immune Cell Fat Switch: Losing RORα Worsens Blinding Eye Disease in Mice
A new mouse study shows that the lipid-sensing nuclear receptor RORα restrains PPARγ-driven fat accumulation in retinal immune cells, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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