Betel Nut Chemical Shields Oral Cancer Cells From Copper-Driven Cell Death
New research shows that arecoline, the main alkaloid in betel nut, activates a ROS-NRF2-MT2A signaling axis that protects oral squamous ...
Tag: NRF2
Liver and Brain Drive Separate Symptoms in Rare Inherited Epilepsy, Mouse Study Finds
A Johns Hopkins mouse study shows that liver dysfunction drives seizures while astrocyte defects in the brain drive psychiatric symptoms ...
Clamworm Compounds Show Promise Against Alcoholic Liver Damage in Mice
Maillard reaction products derived from the marine clamworm Perinereis aibuhitensis protected mice against alcohol-induced liver injury by restoring antioxidant, anti-inflammatory, ...
Old Antipsychotic Meets Mitochondrial Blocker in Two-Drug Strike on Cancer Cells
New research shows that pairing the decades-old antipsychotic chlorpromazine with the mitochondrial fission inhibitor mdivi-1 sharply boosts cancer cell death ...
Low Oxygen Inside Tumors Fuels Cervical Cancer Growth and Cisplatin Resistance, Study Finds
Researchers at Chongqing Medical University report that hypoxia silences the tumor suppressor CCNDBP1 in cervical cancer, activating a USP11–Nrf2 antioxidant ...
Bacterial Toxin Challenge Gets a Timing Makeover in the Hunt for Brain-Saving Plant Compounds
A new review proposes a kinetics- and mechanism-informed framework for using lipopolysaccharide-induced neuroinflammation models to screen phytochemicals with greater rigour ...
Chemical Tag on mRNA Supercharges Scavenger Cells to Heal Dangerous Liver Abscesses
New research shows that the m6A-writing enzyme METTL3 speeds recovery from bacterial liver abscesses by methylating Nrf2 mRNA, which arms ...
Fat Cell Antioxidant Switch Found to Quiet Inflammation in Obesity
Activating the antioxidant regulator NRF2 suppresses STING-driven inflammation in obese fat tissue, but the effect differs sharply between visceral and ...
Melatonin May Offer a Surprising Shield Against Skin Cancer, Review Suggests
A new review in the Archives of Dermatological Research proposes that melatonin, through antioxidant, DNA-repair, and circadian mechanisms, may serve ...
Kale Nanovesicles Boost Cancer Drug’s Kill Switch in Liver Tumor Cells
Researchers at Yeditepe University report that kale-derived exosome-like nanovesicles combined with the dual PI3K/mTOR inhibitor dactolisib trigger apoptosis and alter ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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