Engineered vaccinia virus GC001 shows potent tumour killing and clean safety profile
A thymidine kinase-deleted oncolytic vaccinia virus engineered to silence STRIP1 shows broad anti-tumour activity, ROS-Hippo pathway synergy and a clean ...
Tag: NRF2
Chinese Herb Compound Tetramethylpyrazine May Rewire Damage Response After Spinal Cord Injury
A new review describes how tetramethylpyrazine, an alkaloid from the Chinese herb Ligusticum chuanxiong, may simultaneously block ferroptosis and neuroinflammation ...
Gut Microbes Take the Wheel: How Bacterial Metabolites Remotely Steer the Liver’s Master Antioxidant Switch
A sweeping review in the Journal of Advanced Research details how gut bacterial metabolites such as butyrate, indoles, and urolithins ...
A single ubiquitin enzyme emerges as a master switch between liver repair and liver destruction in MASH
Researchers report that loss of the K63-linked ubiquitination enzyme UBE2N in hepatocytes drives metabolic dysfunction-associated steatohepatitis by blocking p62-mediated mitophagy ...
Common Plant Compound Shields Testes From Chemotherapy Damage in Rat Study
A new rat study shows that protocatechuic acid, a natural plant-derived phenolic compound, protects testicular tissue from cisplatin-induced oxidative damage ...
Zinc-Doped Carbon Dots Shield Sperm Cells From Microplastic Damage
Scientists have engineered zinc-doped carbon dots from a natural flavonoid that protect male fertility from microplastic-induced testicular injury by activating ...
A Traditional Medicinal Root Reveals Antioxidant and Anti-Inflammatory Potential in New Study
An integrated study of Liriope platyphylla root identifies 63 lipophilic compounds and shows antioxidant and anti-inflammatory effects in macrophage cells.
Copper and Iron Cell Death Pathways Offer a New Two-Front Attack on Liver Cancer
A new review in Medical Oncology argues that simultaneously targeting copper-triggered cuproptosis and iron-dependent ferroptosis could open a powerful two-front ...
Myeloid Nrf2 loss speeds atherosclerosis by boosting inflammation and hindering cell clearance
Atherosclerosis, the slow silent narrowing of the arteries that underlies most heart attacks and strokes, has long been understood as ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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