Computational Study Identifies Novel CHRM4 Binding Mode for Prostate Cancer
The team utilized a multistage in silico workflow to screen a library of nearly 30,000 compounds, ultimately prioritizing Molecule_001344 for ...
Tag: Non-canonical
STF-62247 Triggers Caspase-Independent Death in Kidney Cancer Cells via Autophagic Dysfunction
Researchers found that STF-62247 triggers caspase-independent cell death in clear cell renal cell carcinoma by disrupting endolysosomal and autophagic machinery ...
FOXO1 Governs Epithelial Barrier Integrity by Regulating Adherens Junction Complexes
Researchers found that FOXO1 drives rapid bacteria-induced epithelial barrier failure through the spatial regulation of the E-cadherin–β-catenin complex independent of ...
Copper cell death splits into two distinct routes converging on mitochondria
A preclinical study in Molecular Cancer reports that elesclomol and neocuproine trigger mechanistically distinct, FDX1-dependent and FDX1-independent forms of copper-driven ...
A true bug rewrites the telomere rulebook with a rare DNA motif
Fluorescence in situ hybridization reveals that the big-eyed bug Geocoris dispar carries the rare ten-letter telomeric motif TTAGGGGTGG, the first ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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