Cellular Recycling Switch SIRT1-FOXO1 May Hold Key to Taming Brain Inflammation
New research shows that the SIRT1-FOXO1 signaling axis acts as a molecular brake on excessive mitophagy and glycolytic metabolism in ...
Tag: neuroinflammation
Stress Hits the Male and Female Hippocampus in Fundamentally Different Ways
A two-hit mouse study reveals that juvenile and adult stress reshape the male and female hippocampus through distinct behavioral, immune, ...
Ginger-Inspired Molecule 6SA Eases Depression by Targeting Brain Immune Signaling
A newly synthesized ginger-inspired TRPV1 agonist, 6SA, reverses corticosterone-induced depressive-like behavior in mice by restoring the Glul-Gm57375 signaling axis in ...
Ginger Compound Zingerone Shows Promise Against Brain Aging in Rat Study
A new rat study shows that zingerone, a ginger-derived compound, dose-dependently protects against D-galactose-induced brain aging by reducing oxidative stress ...
How Microglial Metabolism and Mitochondria Drive Brain Damage After Stroke
A new review integrates mitochondrial quality control, metabolic reprogramming, and NLRP3 inflammasome activation into a single framework explaining how microglia ...
Silencing PLSCR1 Curbs Brain Inflammation and Memory Loss in Alzheimer’s Mice by Dampening the NLRP3 Inflammasome
A new study shows that silencing the protein PLSCR1 reduces inflammatory microglial activation and improves cognition in Alzheimer's model mice ...
Sleep Loss Rewires How Tramadol Acts on the Adolescent Brain
A new rat study finds that sleep deprivation reshapes the neurobiological effects of tramadol in the adolescent brain, altering lipid ...
New Four-Axis Framework Maps the Hidden Diversity of Atypical Alzheimer’s Disease
A new review proposes a four-axis framework of clinical phenotype, biological context, network topography, and tempo to define the heterogeneity ...
Alzheimer’s Disease Beyond Amyloid: What Atherosclerosis Teaches Us About Dementia Risk
A new perspective argues that Alzheimer's disease should be understood through the same multidimensional, risk-based lens that transformed atherosclerosis, with ...
Sleep Loss Sabotages the Brain’s Power Grid, but a Single Protein May Restore It
A new mouse study shows that the protein APPL1 protects the sleep-deprived brain by restoring mitochondrial dynamics through the Rab32 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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