Histone Marks May Hold Alzheimer’s Inflammation in a Persistent State
A new review proposes that histone post-translational modifications sustain neuroinflammation in Alzheimer's disease by encoding pathological immune memory in chromatin.
Tag: neuroinflammation
Trauma-associated microglia drive chronic inflammation after brain injury
Researchers identified trauma-associated microglia that persist chronically after mouse traumatic brain injury and drive exaggerated inflammatory responses and tissue damage.
Brain waste-clearance signals run low in depression, imaging study finds
A 5 Tesla MRI study of 32 patients with major depressive disorder and 35 healthy controls found weaker blood-oxygen and ...
Loss of CADM3 worsens amyloid buildup and synaptic damage in Alzheimer’s mice
A new study reports that CADM3 expression drops in human Alzheimer's brains and that its genetic loss worsens amyloid deposition, ...
Mitochondria-made peptides emerge as preclinical analgesic candidates
Preclinical studies show the mitochondrial peptides humanin and MOTS-c reduce pain across multiple animal models by restoring mitochondrial function, suppressing ...
Microglia Move to Center Stage as Alzheimer’s Therapies Enter a New Era
A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...
Astrocytes Emerge as Unexpected Players in Rare Epileptic Disorder CDKL5
Patient-derived astrocytes and human brain slice models reveal water-transport, immune and cytoskeletal abnormalities linked to CDKL5 loss.
Gut microbes linked to Alzheimer’s, Parkinson’s, Huntington’s and ALS
A new review links gut microbial imbalances to Alzheimer's, Parkinson's, Huntington's and ALS through inflammation, metabolites and the gut–brain axis.
Inflammatory stimulation reshapes microglial vesicle miRNA cargo and modestly alters recipient cells
An in vitro study found that LPS-stimulated microglia enriched miR-155 and increased miR-34a in donor cells and their extracellular vesicles, ...
Astrocytes may drive chronic traumatic encephalopathy, scoping review finds
A PRISMA-guided scoping review of 40 studies argues that astrocytes act as early, active contributors to chronic traumatic encephalopathy rather ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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