Intrathecal Stem Cell Therapy Reshapes CSF Proteins, Not Blood Immune Cells, in Progressive MS Trial
An integrated blood and CSF multi-omics analysis of the SMART-MS randomized trial found that intrathecal mesenchymal stem cell therapy in ...
Tag: neuroimmunology
Short-Term CD8+ T Cell Depletion Alters Tau Pathology in Aged Alzheimer’s Model Mice
Brief antibody-mediated depletion of CD8+ T cells in aged APP/PS1 mice left amyloid plaques unchanged but reduced dystrophic neurites and ...
AI in MS, NMOSD, autoimmune encephalitis and MOGAD: promise still outruns proof
A new review finds AI applications in CNS autoimmune diseases are expanding rapidly, yet no model has been prospectively validated ...
Rare Autoimmune Cerebellar Ataxia Linked to Lymphoma in New Case Report
A case report describes the first known link between anti-Homer3 antibody-positive autoimmune cerebellar ataxia and diffuse large B-cell lymphoma, while ...
Microglia and immune signaling as architects of the brain
Microglia, the brain's resident immune cells, deploy cytokines, chemokines, complement proteins, and phosphatidylserine recognition systems to build and refine neural ...
Most Cases of a Rare Autoimmune Brain Disease Are Misdiagnosed as Infection, Chinese Study Finds
A dual-center retrospective study of 42 patients in China found that 64.29 percent of GFAP astrocytopathy cases were diagnosed late ...
Bacteriophage Therapy Shows Promise in Refractory PANDAS Case Despite Rising Antibody Titers
In a first-of-its-kind case report, clinicians describe adjunctive bacteriophage therapy in an 11-year-old girl with severe refractory PANDAS, observing sustained ...
Lab-grown human stem cells reveal a shared origin for the brain and body’s immune sentinels
A human stem-cell model recreates early yolk sac immune development and shows that a single progenitor population can generate specialized ...
Gene Found That Lets Transplanted Blood Stem Cells Rebuild the Brain’s Immune Defenses
Stanford researchers used a CRISPR screen in expanded blood stem cells to identify Elp1 as an essential regulator of myeloid ...
Cerebrospinal fluid signals breach the ventricular border in multiple sclerosis
A new Nature Neuroscience study shows that reactive ependymal cells with disrupted cell adhesion form a failing ventricular border in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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