Misfolded Proteins, Inflammasomes and the Spreading of ASC Specks in Neurodegeneration
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...
Tag: neurodegenerative disease mechanisms
Two SOD1 Aggregate Strains Differ in How Fast ALS-Like Disease Spreads to the CNS
In SOD1G85R mice, sciatic nerve inoculation with two distinct SOD1 aggregate strains transmitted templated aggregation to the CNS, with strain ...
Blocked protein cleanup reroutes toxic TDP-43 cargo through extracellular vesicles
In motor neuron–like cells, inhibiting the proteasome or autophagy reshapes extracellular vesicle cargo and spreads proteotoxic stress to recipient cells.
Oligodendroglial Alpha-Synuclein Rewires Midbrain Gene Programs Before Nigral Cell Loss in Mouse Model of MSA
In a mouse model of multiple system atrophy, oligodendroglial alpha-synuclein drives early ventral midbrain transcriptional changes in mitochondrial, metabolic and ...
Chronic Demyelination Traps Microglia in a Lysosomal Cholesterol State
A Nature Neuroscience study in mouse models and human multiple sclerosis tissue identifies a pro-inflammatory microglial state marked by lysosomal ...
The interplay between chronobiology, neuroinflammation, and the glymphatic system in neurodegenerative diseases
A conceptual review proposes that disrupted circadian timing may reinforce neuroinflammation, impair glymphatic clearance and alter molecular clock activity.
Esketamine steers microglia away from inflammatory state via NMDAR2A in cell study
In BV2 microglial cells, esketamine suppressed lipopolysaccharide-induced M1 polarization by selectively acting on the NMDAR2A receptor subtype and activating mTOR ...
Why Some Neurons Break While Others Bend: Redox Thresholds Hold the Answer
For decades, neuroscientists have wrestled with one of the most puzzling contrasts in biology: why neurons in the central nervous ...
When the Clock Ticks in the Cell: Exercise Timing Reshapes a Parkinson’s-Linked Enzyme
Scientists studying Parkinson's disease have long focused on the molecular wreckage left behind by faulty genes and misfolded proteins. A ...
The Brain’s Silent Partnership: How Astrocytes and Microglia Talk From Birth to Disease
A new review reveals that astrocytes and microglia engage in lifelong bidirectional communication that shapes brain development, maintains homeostasis, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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