Anethole from Star Anise and Fennel Shows Promise Against Alzheimer-Like Memory Loss in Rats
A common food-grade aromatic compound from star anise and fennel improved spatial working memory, recognition memory, and anxiety-like behavior in ...
Tag: network pharmacology
Herbal Compound Casticin Eases Knee Osteoarthritis Inflammation by Blocking FAK/PI3K/AKT Signalling
Researchers identified casticin as the key active component of Sanse Powder's transdermal release medium and showed it reduces synovial senescence ...
Alzheimer’s Drug Failure Gets a Second Life: Failed Simufilam Scaffold Reborn as PTP1B Inhibitor
Researchers redesigned 52 derivatives of the failed Alzheimer's drug simufilam to target PTP1B, a key enzyme in neuroinflammation, with lead ...
Ancient Chinese Formula Shields the Brain by Rewiring Gut Microbes and Metabolism
A multi-omics study shows that the classical Chinese formula Xijiao Dihuang Decoction protects rats against stroke reperfusion injury by remodeling ...
Why Blockbuster Drugs Fail the Microvessels: Herbal Multi-Target Chemistry Enters the ANOCA Debate
A new review maps how the interconnected molecular pathology of angina with non-obstructive coronary arteries may demand multi-target therapies that ...
Ginseng Fights Fatigue by Switching Off Runaway Autophagy in Muscle Cells
A new mouse study shows that Panax ginseng relieves fatigue by reactivating the PI3K/AKT/mTOR pathway to suppress excessive autophagy and ...
Machine Learning Finds Mango Compound That Targets Diabetes Protein
Machine learning and laboratory experiments have identified TGFBR1 as a novel molecular target of the mango compound mangiferin and shown ...
Plant Compound Hecogenin Emerges as Top Computational Candidate Against Epstein–Barr Virus
A computational screen of 1,000 plant compounds identifies the steroidal saponin hecogenin as a leading multitarget inhibitor candidate against Epstein–Barr ...
Gut Microbe Meets Omega-3: Two Bifidobacterium Strains Transform EPA Into Distinct Autism-Linked Metabolites
New research shows that two Bifidobacterium breve strains metabolize the omega-3 fatty acid EPA into distinct bioactive metabolites that computational ...
Ginseng Compound Rb1 Starves Pancreatic Tumors by Turning Off Their Macrophage Allies
A ginseng-derived saponin suppresses pancreatic cancer in preclinical models by blocking the PI3K-AKT pathway and preventing macrophages from adopting a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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