The Tumor Suppressor CYLD: A Molecular Switchboard Controlled by Chemical Tags
A new review reveals how the tumor suppressor and deubiquitinating enzyme CYLD is switched on and off by phosphorylation, ubiquitination, ...
Tag: Necroptosis
From Glycans to Mitochondria: Women Scientists Map the Frontiers of Cell Death Research
A new Frontiers in Cell Death Research Topic curated by women scientists collects five studies spanning necroptosis, death receptor glycans, ...
Rat Incisors Reveal How Diabetes Drives Inflammatory Cell Death in Teeth
New research links slowed incisor growth in diabetic rats to oxidative stress and RIPK3–MLKL necroptosis signaling within the dental pulp.
USP28 enzyme drives deadly blood vessel damage in sepsis, mouse study reveals
Researchers identify a USP28–NMMHC IIA signaling loop that accelerates endothelial cell death and multi-organ injury in septic mice, revealing a ...
Hydrogen Sulfide Shields the Brain From Stroke Damage by Halting a Violent Form of Cell Death
New research reveals that the notorious gas hydrogen sulfide can protect neurons from reperfusion injury after stroke by suppressing RIPK1-driven ...
Viral Z-RNA Sensor ZBP1 Emerges as a Switch to Turn Cold Tumors Hot for Immunotherapy
Researchers argue that the innate immune sensor ZBP1, which detects left-handed Z-form nucleic acids and triggers necroptosis, can be pharmacologically ...
Plasma Cholesterol and IL-18 Flag Persistent Fatigue in HIV Patients Whose Immunity Never Recovers
A combined metabolomics and cytokine study of HIV immunological non-responders identifies elevated cholesterol and altered IL-18, IP-10, and MIF levels ...
Crushed by Crowding: Tumor Pressure Triggers Cancer Cell Self-Destruction, Study Finds
New research shows that sustained mechanical confinement inside densely packed tumors activates necroptosis in migratory cancer cells, halting metastasis and ...
Scientists Identify HERC4 as the Molecular Switch That Turns TNF Survival Signals Into Cell Death
Researchers have discovered that the protein HERC4 acts as the critical molecular switch that converts TNF survival signalling into cell ...
Molecular Tags of Cell Death: How E3 Ubiquitin Ligases Steer Necroptosis in Cancer
A new review explains how E3 ubiquitin ligases attach molecular tags to the necroptosis machinery, shaping both cancer development and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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