Scientists discover the molecular switch that lets TNF trigger cell death
A new study identifies the E3 ubiquitin ligase HERC4 as the long-sought molecular switch that licenses RIPK1 to initiate TNF-induced ...
Tag: Necroptosis
Cell Death Signature in Gut Lining Predicts Inflammatory Bowel Disease Relapse
A new study shows that a necroptotic-to-apoptotic cell death axis in intestinal epithelial cells, driven by TNF and interferon gamma, ...
Dead Bacteria, Living Protection: Heat-Killed Probiotic Blocks Inflammatory Cell Death to Heal Stomach Ulcers
Heat-killed Bifidobacterium animalis subsp. lactis BB-12 protected mice from indomethacin-induced gastric ulcers as effectively as live probiotics and better than ...
Hidden Brain Protein Reveals New Cell Death Pathway After Concussion
Researchers report that the trafficking protein Snapin drives neuronal PANoptosis after mild traumatic brain injury by disrupting hydrogen sulfide signaling ...
Copper Overload Pushes Cells Toward Death in Wilson Disease
A new review in Cell Death & Discovery links copper overload, mitochondrial failure and regulated cell death pathways including cuproptosis ...
Osteocyte Necroptosis Emerges as Hidden Driver of Steroid-Linked Bone Loss
New research shows that inflammatory necroptotic death of osteocytes drives cortical bone destruction in glucocorticoid-induced osteoporosis through osteocytic osteolysis.
NINJ1: The Membrane-Rupturing Protein That Decides How Cells Die and How Tumors Thrive
A new review in the Journal of Cancer Research and Clinical Oncology examines how the NINJ1 protein executes plasma membrane ...
Mechanisms and Regulation of Necroptosis: Clinical Relevance Explored
Necroptosis—an inflammatory, programmed form of lytic cell death—has moved closer to the center of modern biomedical research. Executed by MLKL ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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