Trapping rogue DNA rings in micronuclei could disarm aggressive tumors
An international research team has shown that rings of extrachromosomal DNA lose their cancer-driving activity when trapped in micronuclei, a ...
Tag: Nature Genetics
Single-cell map shows how pancreatic cancer clones evolve to outsmart treatment
A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...
Pancreatic Cancer Cells Constantly Rewrite Their DNA to Outsmart Treatment
A single-cell analysis of nearly half a million pancreatic cancer cells shows that continuously evolving clones reshape their DNA to ...
Cancer’s Rogue DNA Can Backfire, Trapping Oncogenes in Micronuclei and Slowing Tumors
New research shows that damaged extrachromosomal DNA is trapped in transcriptionally silent micronuclei, impairing cancer cell fitness and predicting better ...
Wartime Ukraine shows why education must count as scientific infrastructure
Researchers behind Ukraine's Biological Data Science Summer School argue in Nature Genetics that wartime science survives only when education and ...
Single-cell atlas of human liver pinpoints scar macrophages as drug target for fibrosis
A 649,295-cell single-cell atlas of human livers has revealed a pro-inflammatory OLR1-positive scar-associated macrophage population that expands across chronic liver ...
Platinum Chemotherapy, Not PARP Inhibitors, Emerges as the Main Driver of Blood Clone Expansion
New research shows carboplatin drives the expansion of TP53-mutant blood clones far more strongly than PARP inhibitors, while inherited homologous ...
Lung Cancer Outsmarts KRAS Drugs Through Two Distinct Escape Routes
MIT researchers have found that lung adenocarcinomas can evade KRAS inhibitors either by amplifying the KRAS gene or by transforming ...
New Genetic Factor Analysis Method Reveals Hidden Shared Roots of Disease
A new Bayesian method called genetic factor analysis decomposes genome-wide association data into shared pleiotropic factors, revealing the hidden genetic ...
Diverse Biobank Data Sharpen Genetic Risk Prediction Where It Matters Most
A new Nature Genetics study shows that the diversity of the All of Us Research Program improves polygenic risk score ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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