When Oxygen Runs Low: Hypoxia Reshapes IL-12 and IFN-γ as Prognostic Markers in Intracellular Infection
A rat model study shows that hypoxia modulates IL-12 and IFN-γ cytokine dynamics during mycobacterial infection, with early IFN-γ levels ...
Tag: Mycobacterium tuberculosis
How Malnutrition and Thyroid Hormones May Shape Tuberculosis Risk Through the Endocrine-Immune Axis
A new review proposes that micronutrient deficiencies, thyroid dysfunction, and impaired antimycobacterial immunity form a self-perpetuating cycle that may shape ...
Nigeria launches DNA sequencing surveillance to catch drug-resistant tuberculosis missed by routine tests
Nigeria's first sequencing-based surveillance program for drug-resistant tuberculosis uncovered rifampicin and isoniazid resistance missed by routine drug susceptibility tests, demonstrating ...
Massive Molecular Screen Targets a Fatal Weak Point in Tuberculosis Transcription Machinery
Researchers screened more than 87,000 compounds against the essential interaction between the tuberculosis bacterium's RNA polymerase and the transcription factor ...
Computational Screening Points to Two Quinoline Candidates Against Tuberculosis and Resistant Infections
Computational screening of four halogenated quinoline derivatives identifies QNL1 and QNL3 as promising oral drug candidates against tuberculosis, E. coli, ...
Tuberculosis Bacteria’s Secreted Proteins Emerge as New Drug Targets
A new review maps the secreted virulence proteins of Mycobacterium tuberculosis, from ESAT-6 to the antigen 85 complex, and assesses ...
Targeted Sequencing Outperforms Smears in Spotting Hidden Lung Infection Pathogens
A large Chinese cohort study found that both metagenomic and targeted next-generation sequencing of lung fluid outperformed conventional tests for ...
Experimental Tuberculosis Vaccine Targets Rare Variable Antigens to Protect Lungs Without Cutting Bacterial Burdens
A DNA vaccine encoding rare variable antigens of Mycobacterium tuberculosis prevented lung necrosis in susceptible mice without reducing bacterial burdens, ...
Scientists Build Screening Toolkit to Find Bait Ligands for Antibacterial Protein Degradation Drugs
Researchers have developed fluorescence polarization and thermal shift screening methods to identify small-molecule bait ligands for the bacterial ClpC N-terminal ...
Tiny RNA Molecule May Explain Why Some People Resist Tuberculosis Infection
A new PLOS Pathogens study finds that the microRNA-1246 regulates macrophage lipid metabolism and helps explain why some household contacts ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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