Migrasomal miRNA reduces bone loss in mouse osteoporosis model
Pre-osteoblast-derived migrasomes delivered miR-21a-5p to inhibit osteoclast differentiation in cell assays and reduced bone loss in an ovariectomy mouse model.
Tag: MYC
Protonation reshapes MmpL3 to coordinate mycobacterial lipid transport
Molecular dynamics simulations show that protonation at two conserved sites in MmpL3 favors distinct conformations and changes how a key ...
Immune Signaling Complexes Revealed as Unexpected Master Regulators of the MYC Oncogene
A new perspective article argues that CBM immune signaling complexes regulate the MYC oncogene through transcription, physical binding, and protein ...
Single-cell map shows how pancreatic cancer clones evolve to outsmart treatment
A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...
Single-cell atlas reveals how hidden clones drive pancreatic cancer’s deadly evolution
A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...
Pancreatic Cancer Cells Constantly Rewrite Their DNA to Outsmart Treatment
A single-cell analysis of nearly half a million pancreatic cancer cells shows that continuously evolving clones reshape their DNA to ...
USP7: The Double-Edged Deubiquitinase That Tumors Cannot Live Without
A new review in Cancer Cell International maps how the deubiquitinase USP7 acts as both tumor promoter and suppressor depending ...
Fat-Filled Droplets Power the Deadliest Childhood Brain Tumours
New research shows that high-risk Group 3 and Group 4 medulloblastoma cells accumulate cholesterol ester-rich lipid droplets that support energy ...
Super Elongation Complex Found to Switch On Genes That Transform Cell Identity
New research shows that the Super Elongation Complex drives both stem cell reprogramming and neural differentiation by releasing paused RNA ...
Pan-Cancer Cell Atlas Shows How Tumors Team Up to Colonize Bone
A pan-cancer single-cell atlas of nearly 900,000 cells shows that bone metastases from ten cancer types share convergent malignant programs ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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