RNA-processing enzyme Star-PAP stabilizes insulin receptor mRNA and guards fat tissue
A rare Star-PAP variant found in lean individuals led researchers to discover that this polyadenylation enzyme stabilizes insulin receptor mRNA ...
Tag: mRNA stability
NAT10 and USP19 jointly stabilize CDH3 to drive colorectal cancer growth and immune evasion
A new study reports that NAT10-mediated mRNA acetylation and USP19-mediated deubiquitination jointly stabilize CDH3, promoting colorectal cancer progression and immune ...
Circular RNA circCDYL2 drives invasion and migration in nasopharyngeal carcinoma
A new study shows that the circular RNA circCDYL2 stabilizes CDC42 mRNA by recruiting PTBP1, promoting cytoskeletal remodeling that enhances ...
RNA methyltransferase NSUN2 stabilizes PARP9 transcript to drive breast cancer growth and immune escape, study finds
A new Cell Division study reports that the RNA methyltransferase NSUN2 stabilizes PARP9 mRNA through m5C modification read by YBX1, ...
Smoke lowers RNA methylation enzyme WTAP, stabilizing pIgR to curb lung inflammation in mice
A mouse and cell study finds that smoke inhalation lowers the m6A methyltransferase WTAP, which stabilizes pIgR messenger RNA and ...
New spatial sequencing method maps RNA turnover kinetics across the mouse brain
Spatial NT-seq combines metabolic RNA labeling with in situ chemical recoding to co-map newly synthesized and pre-existing RNAs, revealing the ...
Hidden Molecular Shield Lets Lung Cancer Cells Dodge Copper-Driven Cell Death
Researchers have mapped a USP11-IGF2BP2-ATOX1 molecular axis that shields non-small cell lung cancer cells from copper-induced cuproptosis, revealing new drug ...
RNA acetylation enzyme NAT10 drives aortic valve calcification through PCSK9
A new iScience study shows that the RNA acetyltransferase NAT10 stabilizes PCSK9 mRNA through N4-acetylcytidine modification, driving the osteogenic transformation ...
RNA-Binding Protein ADAR2 Throttles Bladder Cancer Spread by Destroying Fat-Making Enzyme Message
A new study shows that the RNA-binding protein ADAR2 suppresses bladder cancer metastasis by destabilizing FASN mRNA and curbing fatty ...
Estrogen receptor fuels breast cancer growth through an RNA-tagging loop, study finds
New research reveals that estrogen receptor alpha drives an m6A-dependent RNA stabilization pathway through HNRNPC and DDX6 that promotes the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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