Tag: mRNA delivery

A new review charts how in vivo CAR-T engineering could transform customized living drugs into scalable, off-the-shelf genetic medicines.

Researchers redesigned lipid nanoparticles to cut liver accumulation of locally injected mRNA by up to eighty-fold in mice while preserving ...

MIT researchers have engineered ligand-directed lipid nanoparticles that reprogram natural killer cells into CAR-bearing cancer killers directly inside living animals, ...

Researchers converted Duchenne patient stem-cell teratomas into humanized models in which both gene-corrected cell transplants and lipid nanoparticle base editing ...

Researchers have engineered a custom ionizable lipid nanoparticle that delivers CAR-encoding mRNA into human T cells with over 90 percent ...

A new review in Advanced Composites and Hybrid Materials presents virus-like particles as adaptable biohybrid nanomaterials uniting established vaccines with ...

A new Nature Biotechnology study shows that screening ionizable lipids with gene-editor-sized RNA cargo identified LC-1, a lipid nanoparticle formulation ...

Researchers at the University of Toronto engineered an ionizable lipid, LC-1, that preserves its fusogenic structure when loaded with large ...

A new Nature Reviews Bioengineering review details how machine learning is transforming nanoparticle drug delivery design, from formulation optimization and ...

Newly developed charge-switching S-lipids keep lipid nanoparticles neutral in circulation but cationic inside acidic endosomes, enabling nucleic acid delivery with ...