Lactate Overload Blocks Kidney Recovery by Crippling Mitochondria Through MRS2
A new study shows that lactate accumulating during reperfusion drives maladaptive metabolic reprogramming in acute kidney injury by triggering MRS2-dependent ...
Tag: mitochondrial dysfunction
Metabolism Holds the Key to the Senescence Secretome
A Cell Research perspective argues that cellular metabolism acts as the licensing mechanism that determines the composition and intensity of ...
Astrocyte model of Batten disease reveals mitochondrial and metabolic defects
In a development that could reshape how scientists understand and ultimately treat one of the most devastating childhood neurodegenerative conditions, ...
ZNF143 drives fatty liver disease by suppressing mitophagy through SMURF1/TRPV1
A team of researchers in China has uncovered a previously unrecognized molecular pathway that drives metabolic dysfunction-associated steatotic liver disease ...
Metformin restores mitochondrial quality control in Down syndrome fibroblasts
Mitochondrial dysfunction has long been recognized as a central feature of Down syndrome, but the precise reasons why the cell's ...
Tau protein linked to Alzheimer’s disrupts nerve cells’ energy-producing mitochondria
A newly identified mechanism may explain how tau protein helps drive Alzheimer’s disease and other tauopathies, according to research from ...
Considerations for Combination Therapies Aiming Disease Modification in Parkinson’s
A new analysis published in npj Parkinson’s Disease considers how combination therapies might better slow or modify Parkinson’s disease—an approach ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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