Nerve Fibers Invade the Aging Lens, Revealing How Cataracts Take Hold
A single-cell atlas of 554 human cataract capsules reveals that nerve-like fibers invade the aging lens through an NRG1-ERBB3 signaling ...
Tag: mitochondrial dysfunction
Hidden Protein Networks Emerge as Central Players in Huntington’s Disease
A new review argues that Huntington's disease is driven by widespread disruptions of interconnected protein networks, pointing to hub proteins ...
Mitochondrial Assembly Factor NDUFAF2 Emerges as Driver of Deadly Aortic Aneurysms
A new iScience study identifies the mitochondrial complex I assembly factor NDUFAF2 as a key promoter of abdominal aortic aneurysm, ...
Gut Microbes Turn Amino Acid Into Toxin That Worsens Pancreatitis in the Elderly
New research in Microbiome shows that age-related expansion of Escherichia-Shigella bacteria in the gut elevates phenylalanine-derived metabolites that damage pancreatic ...
Heart Metabolism, Not Genes, Drives the Signature of Inherited Heart Muscle Disease
A systematic review of 14 genetically characterised studies finds that hypertrophic cardiomyopathy produces a shared metabolic signature of energy deficiency ...
Microplastics and BPA Together Weaken Fish Antiviral Defenses Through Oxidative Stress
A new study shows that co-exposure to microplastics and bisphenol A suppresses NRF2-mediated antioxidant defense in largemouth bass, triggering oxidative ...
Scientists Discover a Molecular Switch That Drains Sperm of Their Swimming Power at High Altitude
New research identifies the free fatty acid receptor FFAR4 as a key mediator of high-altitude hypoxia-induced sperm motility loss, showing ...
Airborne Benzene Linked to Fatty Liver Disease Through Faster Biological Aging
A UK Biobank study of more than 400,000 adults finds that long-term low-level benzene exposure raises the risk of non-alcoholic ...
From Reversible to Irreversible: A New Three-Stage Model Redefines Ovarian Metabolic Disease
A new review proposes that polyendocrine metabolic ovarian syndrome progresses through three biological stages, from a reversible plasticity-dominant state to ...
How Failing Cellular Housekeeping Fuels Brain Disease Through a Viral Alarm System
A new review in the Journal of Translational Medicine details how impaired mitophagy allows mitochondrial DNA to trigger cGAS–STING-driven neuroinflammation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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