Tag: mitochondrial dysfunction in neurodegeneration

A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.

A new human cell model shows that astrocytes lacking the prion protein display increased reactivity markers and mitochondrial abnormalities, yet ...

For the first time, researchers have sequenced mitochondrial DNA from individual vulnerable brainstem neurons in Parkinson's disease, revealing extensive deletions ...

A validated PacBio HiFi long-read sequencing workflow detects low-frequency mitochondrial DNA heteroplasmy with near-perfect accuracy and reveals dynamic variant trajectories ...

A new study finds that whole-blood mitochondrial DNA copy number, but not telomere length, clearly distinguishes Parkinson's disease from multiple ...

A new perspective article in npj Parkinson’s Disease (2026) explores how exposure to ionizing radiation could intersect with the biological ...

A groundbreaking study published in Frontiers in Science introduces the glucose ketone index (GKI) as a novel quantitative biomarker to ...

In a groundbreaking study poised to reshape our understanding of neurodegenerative diseases, researchers have unveiled a compelling link between metabolic ...

Alzheimer’s disease (AD), a devastating neurodegenerative condition characterized by cognitive decline and memory loss, continues to elude definitive treatment despite ...

In a groundbreaking study set to redefine our understanding of Parkinson’s disease (PD), researchers have illuminated a critical molecular pathway ...