Scientists discover a fat-burning switch that helps mice resist obesity
Researchers have identified the phosphatase DUSP4 as a key activator of fat-cell thermogenesis through dephosphorylation of CRTC3, a mechanism that ...
Tag: mitochondria
How Failing Mitochondria Turn Cells Into Engines of Ageing Inflammation
A new GeroScience review details how failing mitochondria act as both initiators and amplifiers of cellular senescence and the chronic ...
Heatstroke Depletes a Heart-Protective Lipid, and Restoring It Saves Mice
A new mouse study shows that heatstroke depletes the anti-inflammatory lipid Maresin1 and that restoring it through the cardiomyocyte receptor ...
How Exercise Trains the Immune System to Fight Infection
New research in PLOS Pathogens reveals that exercise drives a protective metabolite pathway that pushes the NLRP3 inflammasome into a ...
Fly Study Reveals How a Single Energy Enzyme Powers Flight Muscle Development
New research in PLOS Genetics shows that the metabolic enzyme Arginine Kinase 1 is essential for Drosophila flight muscle development, ...
Experimental Drug SMIP004 Hunts Down Dormant Cancer Cells Left Behind by Chemotherapy
Researchers report that the mitochondria-targeting compound SMIP004 selectively kills therapy-induced senescent cancer cells by promoting degradation of the AMPK-stabilized metabolic ...
Diabetes Drug Metformin Surprisingly Blocks Ferroptotic Cell Death in Cancer Cells
New research shows that metformin and phenformin suppress cysteine deprivation-induced ferroptosis in cancer cells by dampening mitochondrial hyperpolarization, oxygen consumption, ...
Dementia May Not Be a Brain Disease at All, NIH Scientists Argue
NIH researchers argue that dementia may be the late-life manifestation of a systemic failure of energy regulation rather than a ...
Blocking a Glutamine Enzyme Restores Aging Muscle Power in Mice
University at Buffalo researchers found that inhibiting the glutamine-metabolizing enzyme GLS1 with the drug CB-839 reduced urea buildup, restored mitochondrial ...
How Chemotherapy Wastes Muscle and Fogs the Brain: A New Muscle–Brain Framework Points to Exercise
A new review proposes that chemotherapy damages mitochondria in both skeletal muscle and the brain through a shared inflammatory feedback ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!