Cellular Powerhouse Clues: TCA Cycle Disruptions Linked to Fatigue and Low Mood in Obesity
A translational study links disrupted TCA cycle metabolites to fatigue and reduced motivation in obesity, with brain-region-specific findings in mice.
Tag: mitochondria
Antidepressants Linked to Lower DNA Damage From Oxidative Stress in Large Human Study
New research reports that people actively treated with antidepressants show about 12.5 percent lower oxidative DNA damage than untreated individuals, ...
Scientists uncover the molecular switch that reshapes aging muscle
University of Copenhagen researchers found that declining cardiolipin in mitochondria triggers an ERRĪ³-driven, ROS-mediated switch that trades muscle power for ...
Virus-driven lymphoma cells rely on a mitochondrial enzyme duo to dodge cell death
New research reveals that the mitochondrial ubiquitin ligase MARCHF5 helps KSHV-transformed lymphoma cells survive by degrading NOXA, the natural antagonist ...
Jonathan the 194-Year-Old Tortoise Reveals a Genetic Secret to Aging Slowly
A Vanderbilt-led team sequencing the genome and epigenome of Jonathan, a 194-year-old giant tortoise on St. Helena, found that promoters ...
Diabetes Drug Metformin Shields Lymphatic Vessels from Chemotherapy Damage
New research shows that the diabetes drug metformin protects lymphatic vessels from mitochondrial damage caused by the chemotherapy agent 5-fluorouracil ...
Scientists Wrap Mitochondria in Protective Nanomaterials Without Halting Their Energy Production
Researchers at IRCCS Fondazione Istituto Neurologico Carlo Besta and Politecnico di Milano have shown that mitochondria can be coated with ...
Newborns with congenital diaphragmatic hernia show hyperactive but inefficient mitochondria in endothelial cells
Endothelial cells from newborns with congenital diaphragmatic hernia display hyperactive but inefficient mitochondria, linking cellular energy dysfunction to pulmonary vascular ...
When Chromatin Wobbles, Cells Pay a Metabolic Price, Study Finds
A PLOS Genetics study shows that destabilizing chromatin through a histone H3 mutation hyperactivates the nutrient-sensing TORC1 pathway and triggers ...
Red Light Before Implantation Primes Stem Cell Mitochondria to Rebuild Tracheal Cartilage
Preconditioning stem cells with a defined dose of 660 nm red light reprograms their mitochondria and activates a SOX9-driven chondrogenic ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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