New Mathematical Map Reveals Why Drugs Fail in Patchy Tumors and Biofilms
A new mathematical framework maps how migration and uneven drug penetration across microhabitats determine whether bacterial or cancer cell populations ...
Tag: metastasis
Snail2 Emerges as the Master Switch Behind Partial EMT, Metastasis and Development
A comprehensive review in Cell Death Discovery maps how the transcription factor Snail2 governs partial epithelial-mesenchymal transition, driving both embryonic ...
Metadherin emerges as an invasion switch in oral squamous cell carcinoma
New research shows that metadherin, enriched at the invasive front of oral squamous cell carcinoma, drives tumor invasion by selectively ...
RNA-Binding Protein ADAR2 Throttles Bladder Cancer Spread by Destroying Fat-Making Enzyme Message
A new study shows that the RNA-binding protein ADAR2 suppresses bladder cancer metastasis by destabilizing FASN mRNA and curbing fatty ...
How Shapeshifting Tumor Cells Outsmart Cancer Treatment
A new review explains how tumor cells reversibly switch identities through epigenetic and microenvironmental programs, driving metastasis and therapy resistance.
Ancient Herbal Formula Meets Modern Oncology in Landmark Gastric Cancer Trial
A twelve-hospital, double-blind, placebo-controlled trial in China will test whether the traditional herbal formula Yiqi Huayu Jiedu Decoction combined with ...
Serotonin Receptor Found to Drive Bone Cancer Spread and Chemotherapy Failure
Researchers report that the serotonin receptor HTR1D drives osteosarcoma metastasis and doxorubicin resistance through a c-MYC/MAPK feedback loop and CCL2/5-HT-mediated ...
Iron-Powered Cell Death Emerges as Double-Edged Sword in Cancer’s Microenvironment
A new review in Medical Oncology maps how the tumor microenvironment can either amplify or suppress ferroptosis, the iron-dependent cell ...
Scientists Engineer Shear-Resistant Prostate Cancer Cells and Uncover a Survival Gene
Researchers have created the first stable prostate cancer cell lines resistant to blood-flow-level shear stress and identified the calcium-buffering gene ...
Cancer Cells Turn Fat Factories: SOX9 Fuels Colorectal Cancer Spread Through Lipid Rewiring
New research reveals that the transcription factor SOX9 drives colorectal cancer metastasis by directly activating the fat-synthesizing enzyme FASN, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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