Observational genome study links eight processes to most prostate cancer DNA damage
An observational analysis of 959 prostate tumours from 1,001 men found that eight cellular processes account for 85% of DNA ...
Tag: metastasis
HOTAIR functions as a context-dependent cancer regulator, review finds
A review finds that HOTAIR links chromatin remodeling, tumor progression, metabolic adaptation and treatment resistance through functions that vary by ...
PRKAR2A Emerges as Candidate Spatial cAMP–PKA Router in TNBC
A critical review finds that PRKAR2A is a plausible spatial regulator of cAMP–PKA signalling in triple-negative breast cancer, although current ...
How a high-fat diet may help colon cancer spread to the liver
MIT biologists have identified a YAP1-driven regenerative pathway, activated by diet-derived ceramides, that colorectal cancer cells hijack to metastasize to ...
Ovarian Cancer Cells Depend on USP15 Enzyme, Offering a Sharper Therapeutic Target
UMBC researchers found that ovarian cancer cells depend heavily on the enzyme USP15, and reducing it slows tumor growth, disrupts ...
Computational Study Links Metabolic Enzyme NNMT to a Triple Shield That Lets Cancer Cell Clusters Survive in the Bloodstream
A new computational framework links the metabolic enzyme NNMT to coordinated platelet, neutrophil, and immune exhaustion programs in circulating tumor ...
Severe Pain and Low Opioid Doses Predict Who Responds Best to Nerve Blocks for Cancer Pain
A retrospective study of 349 hospitalized cancer patients found that higher baseline pain intensity and lower opioid doses independently predicted ...
ENO3 Emerges as a Lactate-Linked Biomarker in Colorectal Cancer Metastasis
Integrated transcriptomic analysis of TCGA and GEO datasets identifies a six-gene lactate metabolism signature and nominates ENO3 as a prognosis-associated ...
Hidden RNA splice variant drives colorectal cancer spread, study finds
A tumor-specific splice variant of CALD1, driven by the splicing factor hnRNPA1 and acting through the motor protein MYH9, promotes ...
Thirteen Years Cancer-Free, Then a Seizure: Rare Brain Metastasis Stuns Doctors
A 58-year-old man developed a solitary brain metastasis from gastroesophageal junction adenocarcinoma thirteen years after curative treatment, a case that ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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