SRPX2 Emerges as a Master Switch Behind Colorectal Cancer Spread and Immune Evasion
New research identifies the secreted protein SRPX2 as a molecular switch that stabilizes the TGF-beta receptor to drive metastasis and ...
Tag: metastasis
Molecular Hydrogen Emerges as a Versatile Adjuvant in Cancer Therapy
A new review in Frontiers in Chemical Biology maps how molecular hydrogen reprograms oncogenic signaling, epigenetics, mitochondrial stress, and antitumor ...
CT-to-surgery interval and occult nodal metastasis in cN0 oral squamous cell carcinoma
A retrospective study of 329 patients with clinically node-negative oral squamous cell carcinoma examined whether the interval between CT staging ...
Single-cell and bulk transcriptomic characterization of the osteosarcoma microenvironment reveals lineage-specific programs and inflammatory differences associated with metastasis
Osteosarcoma has long frustrated oncologists. It is the most common primary malignant bone tumor, striking hardest in adolescents, and while ...
Rare Sarcomas With Shared Genes Follow Two Very Different Paths, Study Finds
A Portuguese reference-centre study of twenty patients shows that low-grade fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma, though molecularly related, follow ...
Marine Fungus Compound MHO7 Blocks Spread of Triple-Negative Breast Cancer by Disabling FAK Signaling
A marine-derived fungal sesterterpenoid called MHO7 suppresses the migration and invasion of triple-negative breast cancer cells by inhibiting the FAK ...
Hidden Switch Lets Melanoma Cells Flip Into Metastasis Mode, Study Finds
Researchers in Milan have identified MyD88 as a tumor cell-intrinsic switch that sustains a metastasis-competent, integrin-driven cell state in NRAS-mutant ...
Crushed by Crowding: Tumor Pressure Triggers Cancer Cell Self-Destruction, Study Finds
New research shows that sustained mechanical confinement inside densely packed tumors activates necroptosis in migratory cancer cells, halting metastasis and ...
How Pancreatic Cancer Cells Survive Detachment: Autophagy Emerges as Key to Spread
Researchers at Lund University have shown that pancreatic cancer cells engineered to survive detachment consistently switch on autophagy and ubiquitin ...
Regulatory Immune Cells Rise With Lung Cancer Severity, Blood Study Finds
A prospective case-control study reports that circulating regulatory B cells, regulatory T cells, and a broad serum cytokine panel are ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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